PMID: 8948497Nov 14, 1996Paper

Inducibility of cytochromes P-450 by dioxin in liver and extrahepatic tissues of the marmoset monkey (Callithrix jacchus)

Biochimica Et Biophysica Acta
T G SchulzR J Edwards

Abstract

Cytochrome P-450 induction was investigated in the marmoset monkey, a non-human primate, using dioxins as inducing agents. Animals received a single subcutaneous dose of 1.6 nmol tetrachlorodibenzo-p-dioxin or tetrabromodibenzo-p-dioxin/kg body weight. Microsomal fractions were prepared from liver, lung and kidney, and homogenates were prepared from gut and adrenal glands. Anti-peptide antibodies which bind to CYP1A1, CYP1A2, CYP2B6 and CYP3A4 in human were used to identify related forms in the marmoset. The results indicate that CYP1A2 is constitutively expressed in liver, but not in lung, kidney, gut or adrenal gland and that CYP1A1 is not expressed in any of these tissues in untreated animals. Treatment with dioxin induced both CYP1A1 and CYP1A2 in liver, but only CYP1A1 in lung. No induction of CYP1A1 or CYP1A2 was found in kidney, small intestine or adrenal glands. Methoxy-, ethoxy-, pentoxy- and benzoyloxyresorufin O-dealkylases and high affinity phenacetin O-deethylase activities were induced in the liver, whereas ethoxycoumarin O-deethylase and aryl hydrocarbon hydroxylase activities were not affected by dioxin treatment. High-affinity phenacetin O-deethylase and CYP1A2 apoprotein were detected only in liver, consistent...Continue Reading

References

Sep 15, 1991·The Biochemical Journal·R J EdwardsD S Davies
Jan 1, 1991·Methods in Enzymology·R J EdwardsA R Boobis
Oct 1, 1991·Archives of Biochemistry and Biophysics·D J WaxmanK Korzekwa
Jun 1, 1990·British Journal of Clinical Pharmacology·D SesardicD S Davies
Nov 1, 1983·European Journal of Cancer & Clinical Oncology·M LodoviciA Calzolai
Dec 1, 1982·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·W P McNultyM L Gross
Jun 1, 1994·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·S E ClarkeR J Chenery

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Citations

Dec 5, 1998·Chemosphere·M CamatiniC Urani
Aug 8, 2001·Marine Environmental Research·O M HyytiO Pelkonen
Mar 21, 2001·Biochimica Et Biophysica Acta·T G SchulzR J Edwards
Oct 7, 2011·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Brian R CookeMichael Hall
Apr 16, 1998·Biochimica Et Biophysica Acta·T G SchulzR J Edwards

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