Inducible and cell-type restricted manipulation in the entorhinal cortex

Neuron
Kazu Nakazawa

Abstract

The entorhinal cortex functions as the gateway to the hippocampal formation. However, its role in formation and consolidation of hippocampus-dependent memory remains relatively unexplored. In this issue of Neuron, Yasuda and Mayford report an elegant cell-type restricted inducible transgenic mouse overexpressing a mutant form of CaM kinase II selectively in superficial layers of medial entorhinal cortex and its upstream regions. These animals display a selective spatial memory deficit during the immediate posttraining period as well as during acquisition in the Morris water maze. Similar to the hippocampus, this time-limited involvement of entorhinal cortex in spatial memory processing suggests a crucial role for hippocampal-entorhinal circuitry in spatial memory formation.

References

Sep 20, 1991·Science·L R Squire, S Zola-Morgan
Feb 1, 1957·Journal of Neurology, Neurosurgery, and Psychiatry·W B SCOVILLE, B MILNER
Jul 1, 2004·Hippocampus·Leonard E JarrardBeverly Bowring
Jan 25, 2005·Neuron·Hill-Aina SteffenachEdvard I Moser
Jun 21, 2005·Nature·Torkel HaftingEdvard I Moser
Jul 13, 2005·Neuropsychologia·Gordon WinocurMalcolm A Binns

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