Inducible but not endothelial nitric oxide synthase polymorphism is associated with susceptibility to rheumatoid arthritis in northwest Spain

Rheumatology
M A Gonzalez-GayJ Martín

Abstract

To assess the influence of inducible and endothelial nitric oxide synthase (iNOS and eNOS) polymorphisms in susceptibility to rheumatoid arthritis (RA). Two hundred RA patients fulfilling the 1987 American College of Rheumatology classification criteria followed at the out-patient rheumatology clinic of the Hospital Xeral-Calde (Lugo, Spain) and 251 ethnically matched controls were studied. Patients and controls were genotyped by PCR-based techniques for a multiallelic (CCTTT)(n) repeat in the promoter region of the iNOS gene and for a T/C polymorphism at position -786 in the promoter region and a polymorphism in exon 7 (298Glu/Asp or 5557G/T) of the eNOS gene. No significant difference in allele or genotype frequencies for either polymorphism in the eNOS gene was observed between RA patients and controls. The overall iNOS CCTTT(n) allelic or genotypic distribution did not show statistical significant differences between RA patients and controls. Interestingly, when we stratified the iNOS alleles into short (8-11) and long (12-16) repeats, significant differences were observed between RA patients and controls (P = 0.021; odds ratio = 1.37, 95% confidence interval 1.04-1.81). Of note, individuals carrying two alleles with a repe...Continue Reading

Citations

Jan 21, 2014·Archivos de bronconeumología·Adolfo Baloira VillarDiana Valverde Pérez
Dec 10, 2013·Journal of the Chinese Medical Association : JCMA·Zhon-Min HuangGuang-Dar Juang
Jun 30, 2012·Nitric Oxide : Biology and Chemistry·Yan-Fei MaoJun-Long Huang
Jul 29, 2009·Nitric Oxide : Biology and Chemistry·Jezabel VaradéElena Urcelay
Apr 28, 2009·Journal of Diabetes and Its Complications·Renata A BagarolliSara Teresinha O Saad
Jun 15, 2007·Immunology Letters·György NagyAndrew P Cope
Nov 28, 2015·Rheumatology International·Vera BunjevackiTatjana Damnjanovic
Dec 21, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L I HollaA Vasku
Aug 8, 2006·Nitric Oxide : Biology and Chemistry·Victor AsensiAntonio Celada
Mar 4, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Fozia Khan, Asim A Siddiqui
Aug 9, 2005·Seminars in Arthritis and Rheumatism·Miguel A Gonzalez-GayJavier Martin
Apr 5, 2017·International Journal of Immunogenetics·V S NegiR Tamouza
Jan 9, 2018·World Journal of Gastroenterology : WJG·Nezha SenhajiJavier Martín
Mar 8, 2019·Journal of Immunoassay & Immunochemistry·Rizwan AhmadHaseeb Ahsan
May 31, 2006·World Journal of Gastroenterology : WJG·Tryggve LjungPer M Hellstrom

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