Inducible-costimulator-mediated suppression of human immunodeficiency virus type 1 replication in CD4(+) T lymphocytes

Virology
Xin ZhouMari Kannagi

Abstract

We investigated the effects of signaling through CD28 family molecules on human immunodeficiency virus type 1 (HIV-1) replication in vitro. A monoclonal antibody (mAb) specific for inducible costimulator (ICOS) suppressed both X4 and R5 HIV-1 replication in CD4(+) peripheral blood mononuclear cells (PBMC). This suppression was not attributable to reduced cell growth or viability. CD28 mAb showed variable effects and also suppressed HIV-1 replication when immobilized. Replication of pseudotype viruses with HIV-1-but not with vesicular stomatitis virus G-envelope was efficiently suppressed in CD4(+) PBMC treated with ICOS or CD28 mAbs. However, CD4, CXCR4, and CCR5 expression on the surface was not down-regulated. Moreover, HIV-1 replication in CD4(+) PBMC was suppressed by a soluble form of human B7-H2, a ligand of ICOS, but was enhanced by soluble B7-1, a ligand for CD28. These findings suggest that natural or artificial ligands for ICOS potentially suppress HIV-1 replication mainly at the entry stages.

References

Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P S LinsleyJ A Ledbetter
Dec 14, 1989·The New England Journal of Medicine·D D HoM Alam
Jul 16, 1987·Nature·J F BrunetP Golstein
Jul 23, 1987·Nature·B D WalkerR T Schooley
Aug 1, 1995·The Journal of Experimental Medicine·M F Krummel, J P Allison
Nov 4, 1993·Nature·M AzumaC Somoza
Aug 1, 1994·Immunity·T L WalunasJ A Bluestone
Jan 1, 1996·Annual Review of Immunology·D J LenschowJ A Bluestone
Dec 23, 1999·International Immunology·T TamataniN Hanzawa-Higuchi
Apr 3, 2001·The Journal of Experimental Medicine·S Y TsengH Tsuchiya
Apr 27, 2001·Trends in Immunology·H Nishimura, T Honjo
Feb 6, 2002·The Journal of Clinical Investigation·Kenneth A Frauwirth, Craig B Thompson
Feb 13, 2002·Hybridoma and Hybridomics·S SakamotoT Tamatani
Mar 26, 2002·Nature Reviews. Immunology·Arlene H Sharpe, Gordon J Freeman
Aug 2, 2003·Biochemical and Biophysical Research Communications·Pornpan YoungnakMiyuki Azuma

❮ Previous
Next ❯

Citations

Mar 18, 2005·Annual Review of Immunology·Rebecca J GreenwaldArlene H Sharpe
Jul 21, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mandy BusseGesine Hansen
Apr 23, 2020·Journal of Autoimmunity·Carlo PerriconeRoberto Gerli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.