Inducible interleukin 4 (IL-4) production and mRNA expression following exposure of mice to chemical allergens

Toxicology Letters
C A RyanF Gerberick

Abstract

Previous investigations have indicated that different classes of chemical allergen provoke discrete immune responses in mice characterized by the development of selective cytokine secretion patterns by draining lymph node cells. It was found that, in mice exposed chronically to chemical respiratory allergens, lymph node cells produced high levels of mitogen-inducible interleukin 4 (IL-4), a cytokine necessary for the development of IgE antibody responses. In contrast, exposure of mice to contact allergens resulted in only low levels of IL-4 production. The studies described here were conducted to determine whether differentially induced expression of IL-4 messenger RNA was independent of the need for mitogen stimulation, unlike secretion of IL-4 protein. Mice were exposed to concentrations of trimellitic anhydride (TMA), a respiratory allergen, or to 2,4-dinitrochlorobenzene (DNCB), a contact allergen, under conditions of equivalent immunogenicity and where the former, but not the latter, resulted in significant production of mitogen-inducible IL-4 protein. The steady state levels of IL-4 mRNA in draining lymph nodes were measured by reverse transcription-polymerase chain reaction after a single or repeated daily application of...Continue Reading

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Citations

Nov 7, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R J DearmanI Kimber
Apr 5, 2003·Toxicology Letters·Josje H E Arts, C Frieke Kuper
Nov 26, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ian KimberRebecca J Dearman
May 24, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·N J HoldenS C Knight
Nov 21, 2008·Journal of Applied Toxicology : JAT·Rebecca Jane DearmanIan Kimber
Mar 22, 2002·Toxicology and Applied Pharmacology·L M PlitnickR J Smialowicz
Dec 13, 2006·Methods : a Companion to Methods in Enzymology·Josje H E Arts, C Frieke Kuper
Apr 5, 2001·Journal of Applied Toxicology : JAT·R J Dearman, I Kimber
Aug 3, 2018·Current Allergy and Asthma Reports·Calvin T SungSharon E Jacob
Mar 3, 2012·Nature·Michael F SterzikEnric Palle
Jul 1, 2020·Clinical Reviews in Allergy & Immunology·Debajyoti Ghosh, Jonathan A Bernstein
May 12, 2006·Critical Reviews in Toxicology·Josje H E ArtsCees de Heer
Jun 15, 2007·Alternatives to Laboratory Animals : ATLA·Ian KimberUNKNOWN European Centre for the Validation of Alternative Methods

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