Inducible MicroRNA-3570 Feedback Inhibits the RIG-I-Dependent Innate Immune Response to Rhabdovirus in Teleost Fish by Targeting MAVS/IPS-1

Journal of Virology
Tianjun XuDekun Bi

Abstract

Effectively recognizing invading viruses and subsequently inducing innate antiviral immunity are essential for host antiviral defense. Although these processes are closely regulated by the host to maintain immune balance, viruses have evolved the ability to downregulate or upregulate these processes for their survival. MicroRNAs (miRNAs) are a family of small noncoding RNAs that play vital roles in modulating host immune response. Accumulating evidence demonstrates that host miRNAs as mediators are involved in regulating viral replication and host antiviral immunity in mammals. However, the underlying regulatory mechanisms in fish species are still poorly understood. Here, we found that rhabdovirus infection significantly upregulated host miR-3570 expression in miiuy croaker macrophages. Induced miR-3570 negatively modulated RNA virus-triggered type I interferon (IFN) and antiviral gene production, thus facilitating viral replication. Furthermore, miR-3570 was found to target and posttranscriptionally downregulate mitochondrial antiviral signaling protein (MAVS), which functions as a platform for innate antiviral signal transduction. Moreover, we demonstrated that miR-3570 suppressed the expression of MAVS, thereby inhibiting M...Continue Reading

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Citations

Jul 4, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tianjun XuJunxia Cui
Dec 14, 2018·Frontiers in Immunology·Man WangKun Wang
Aug 6, 2019·Frontiers in Immunology·Morgan Brisse, Hinh Ly
May 7, 2020·Frontiers in Immunology·Xiaolong YanTianjun Xu
Aug 21, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lei ZhangTianjun Xu
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Dec 22, 2020·Developmental and Comparative Immunology·Xiaomeng RenYuena Sun
Aug 15, 2021·Developmental and Comparative Immunology·Renjie ChangYuena Sun

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