Inducible nitric oxide synthase expression in gastroduodenal diseases infected with Helicobacter pylori

Helicobacter
H J SonJ J Kim

Abstract

Nitric oxide (NO) is synthesized enzymatically from L-arginine by NO synthase, which is measured by inducible NO synthase (iNOS). Helicobacter pylori (H. pylori) infection produces a state of chronic immunostimulation in the gastric epithelium. Infection with cagA+ H. pylori has greater degree of gastric inflammation and epithelial cell damage. Therefore, we compared the levels of iNOS in patients with H. pylori infection in relation to cagA status and H. pylori-related disease. One hundred and seven patients, including 51 patients with gastric cancer, 12 patients with gastric ulcer, 18 patients with duodenal ulcer and 26 patients with chronic gastritis, were enrolled in this study. Biopsies from the antrum and body were obtained for histologic examination, culture and reverse transcriptionase-PCR (RT-PCR) for detection of iNOS gene expression. The presence of H. pylori was confirmed by Giemsa staining or culture and the gene expression of cagA in H. pylori isolates was confirmed by PCR. H. pylori infection was detected in 70.1% (75/107) and cagA was detected in 84.8% (28/33). iNOS expression was detected in 49.5% (53/107) and there was no significant difference in iNOS expression according to H. pylori infection nor the cagA s...Continue Reading

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Citations

Oct 11, 2003·Journal of Gastroenterology and Hepatology·Harry Hua-Xiang Xia, Benjamin Chun-Yu Wong
Feb 27, 2016·Trends in Microbiology·Alain P Gobert, Keith T Wilson
Sep 27, 2005·Helicobacter·Matthias LechnerHerbert Tilg
Jun 8, 2010·Journal of Experimental & Clinical Cancer Research : CR·Juan-Bosco Lopez-SaezAvelino Senra-Varela
Apr 20, 2017·Journal of Oncology·Shyam Singh, Hem Chandra Jha
Mar 15, 2006·World Journal of Gastroenterology : WJG·Brigitte BancelBrigitte Pignatelli
Sep 25, 2020·Journal of Breath Research·Gourab D Banik, Boris Mizaikoff

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