Inducible nitric oxide synthase modulates cyclooxygenase-2 activity in the heart of conscious rabbits during the late phase of ischemic preconditioning

Circulation Research
Ken ShinmuraR Bolli

Abstract

Cyclooxygenase-2 (COX-2) is known to mediate the cardioprotective effects of the late phase of ischemic preconditioning (PC); however, the signaling pathways involved in COX-2 induction following ischemic PC are unknown. In addition, although inducible nitric oxide synthase (iNOS) has been identified as a co-mediator of late PC together with COX-2, the interaction between iNOS and COX-2 in the heart is unknown. Using conscious rabbits, we found that the induction of COX-2 expression 24 hours after ischemic PC was blocked by pretreatment with inhibitors of protein kinase C (PKC), Src protein tyrosine kinases (PTKs), and nuclear factor-kappaB (NF-kappaB) but not by inhibitors of NOS or scavengers of reactive oxygen species (ROS). The selective iNOS inhibitors SMT and 1400W, given 24 hours after PC, abrogated the increase in myocardial prostaglandin E2 (PGE2) and 6-keto-PGF1alpha, whereas the selective soluble guanylate cyclase inhibitor ODQ had no effect. COX-2 selective inhibitors (celecoxib and NS-398) did not affect iNOS activity. These results demonstrate that (i) ischemic PC upregulates cardiac COX-2 via PKC-, Src PTK-, and NF-kappaB-dependent signaling pathways, whereas generation of NO and ROS is not necessary, and (ii) th...Continue Reading

References

May 1, 1994·The Journal of Clinical Investigation·D SalveminiP Needleman
Aug 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D SalveminiP Needleman
Sep 1, 1994·Archives of Biochemistry and Biophysics·A L TsaiR J Kulmacz
May 23, 1998·Annual Review of Pharmacology and Toxicology·J R VaneR M Botting
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·S NogawaC Iadecola
Jul 1, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D C GoodwinL J Marnett
Jul 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·R ClancyS B Abramson
Aug 30, 2000·Proceedings of the National Academy of Sciences of the United States of America·K ShinmuraR Bolli
Oct 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·Y T XuanR Bolli
Dec 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·Xian-Liang TangRoberto Bolli

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Citations

Jan 9, 2007·European Journal of Applied Physiology·Marina MariniArsenio Veicsteinas
Sep 29, 2007·Pflügers Archiv : European journal of physiology·Li-Fang HuJin-Song Bian
Nov 19, 2009·Journal of Anesthesia·Noboru TodaHiroshi Toda
Mar 18, 2006·Apoptosis : an International Journal on Programmed Cell Death·A AbbateA Baldi
Jan 26, 2006·Cardiovascular Drugs and Therapy·Salvatore RosanioYochai Birnbaum
May 25, 2010·Cardiovascular Drugs and Therapy·Derek J Hausenloy, Derek M Yellon
Jun 2, 2007·Heart Failure Reviews·Roberto BolliBuddhadeb Dawn
Jan 8, 2010·The Journal of Physiological Sciences : JPS·John C QuindryScott Powers
Oct 2, 2004·International Journal of Cardiology·Shoji Sanada, Masafumi Kitakaze
Mar 17, 2004·Journal of Neuroimmunology·John W RoseNoel G Carlson
Oct 16, 2003·The Journal of Nutritional Biochemistry·Concepción Sánchez-MorenoAntonio Martín
May 10, 2003·Journal of Molecular and Cellular Cardiology·Yu-Ting XuanRoberto Bolli
Sep 12, 2003·Journal of Molecular and Cellular Cardiology·Adrienn KisGary F Baxter
Apr 8, 2003·Journal of the American College of Cardiology·Ken ShinmuraRoberto Bolli
Apr 8, 2003·Journal of the American College of Cardiology·Karin Przyklenk, Gerd Heusch
Jul 20, 2005·The Journal of Experimental Medicine·Kanji MinamotoDavid J Pinsky
Aug 8, 2007·The Journal of Experimental Medicine·Sruti ShivaMark T Gladwin
Mar 18, 2004·Antioxidants & Redox Signaling·Harjot K SainiNaranjan S Dhalla
Mar 18, 2004·Antioxidants & Redox Signaling·Hajime Otani
Nov 15, 2007·Antioxidants & Redox Signaling·Hajime Otani
Feb 11, 2009·Antioxidants & Redox Signaling·Hajime Otani
Dec 17, 2008·Cardiovascular Research·Christopher M JenkinsRichard W Gross
Jan 4, 2012·Clinical and Experimental Pharmacology & Physiology·Ming ZhaoWei-Jin Zang
Sep 12, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Roberto Bolli
Aug 21, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Hiroshi SatoXian-Liang Tang
Oct 2, 2004·Stroke; a Journal of Cerebral Circulation·Adam B SteinRoberto Bolli
Aug 21, 2008·Anesthesia and Analgesia·Paul S PagelDorothee Weihrauch
Mar 11, 2006·Medicinski pregled·Andelka RistićSasa Rafaelovski
Feb 18, 2005·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Andelka Ristić-AndelkovSaso Rafajlovski
Apr 15, 2014·European Journal of Pharmacology·Christina Alves Peixoto, Bruna Santos Silva
Nov 27, 2010·Journal of Cardiothoracic and Vascular Anesthesia·Paul S Pagel, Judith A Hudetz
Feb 13, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Takayuki KawanoCostantino Iadecola
Dec 17, 2008·Journal of Molecular and Cellular Cardiology·Javier InserteDavid Garcia-Dorado
Jul 28, 2007·Journal of Molecular and Cellular Cardiology·E ShenTianqing Peng

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