Inducible ribosomal RNA methylation in Streptomyces lividans, conferring resistance to lincomycin

Journal of General Microbiology
G JenkinsE Cundliffe

Abstract

Streptomyces lividans TK21 possesses inducible ribosomal RNA methylase activity that confers high-level resistance to lincomycin and lower levels of resistance to certain macrolides. The methylase gene (designated lrm) is inducible by erythromycin and other macrolides and also by celesticetin (a lincosamide) but not by lincomycin. The lrm enzyme monomethylates the N6-amino group of adenosine at position 2058 within 23S-like ribosomal RNA.

Citations

Jan 1, 1992·Folia Microbiologica·Z Jandová, P Tichý
Sep 1, 1995·FEMS Microbiology Letters·M P O'NeillJ H Cove
Feb 1, 1992·Antimicrobial Agents and Chemotherapy·E Cundliffe
Nov 6, 2002·Proceedings of the National Academy of Sciences of the United States of America·Mingfu Liu, Stephen Douthwaite
May 7, 2010·Journal of Industrial Microbiology & Biotechnology·Eric Cundliffe, Arnold L Demain
Feb 10, 2007·The Journal of Antimicrobial Chemotherapy·Catherine V Hawkyard, Roland J Koerner

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