Inducible, transferable resistance to vancomycin in Enterococcus faecalis A256.

Antimicrobial Agents and Chemotherapy
D M ShlaesR Williamson

Abstract

A strain of Enterococcus faecalis (A256) was isolated from the urine of a patient with urinary sepsis and was found to exhibit susceptibilities (micrograms per milliliter) to various glycopeptides as follows: vancomycin, 256; teicoplanin, 16; 62208, 512; 62211, 4; and 62476, 16. As judged by growth rates before and after exposure to sub-MICs of glycopeptides, vancomycin and 62476 induced self-resistance, 62208 and 62211 induced slight self-resistance, and teicoplanin did not induce self-resistance. Vancomycin induced cross-resistance to all other glycopeptides tested, as judged both in growth experiments and by direct measurement of inhibition of peptidoglycan synthesis in cells exposed to sub-MICs of vancomycin. Thus, the spectra of activity of the glycopeptides were not correlated with their patterns of induction. There was a correlation between the increased synthesis of a 39-kilodalton (kDa) protein located in the cytoplasmic membrane and the induction of resistance. Protoplasts of A256 were susceptible to inhibition of peptidoglycan synthesis by vancomycin at levels similar to those for susceptible strains. Vancomycin resistance was transferable on filters from the parent strain to E. faecalis JH2-2 at a frequency of about...Continue Reading

References

Aug 1, 1979·The Journal of Infectious Diseases·R C MoelleringC B Wennersten
Jul 1, 1987·The Journal of Hospital Infection·G Colman, A Efstratiou
Jan 2, 1988·Lancet·A H UttleyR C George
Dec 1, 1987·Antimicrobial Agents and Chemotherapy·B P GoldsteinG Cassani
Jan 1, 1988·The Journal of Antimicrobial Chemotherapy·P LewisF Parenti
Jul 21, 1988·The New England Journal of Medicine·R LeclercqP Courvalin
Jul 1, 1986·Journal of General Microbiology·R WilliamsonJ F Acar
Jun 1, 1988·Journal of Clinical Microbiology·A H KaplanR R Facklam
Apr 9, 1987·The New England Journal of Medicine·R S SchwalbeP H Gilligan
Sep 1, 1985·Antimicrobial Agents and Chemotherapy·A Buu-HoïJ F Acar
May 10, 1974·Annals of the New York Academy of Sciences·H R Perkins, M Nieto
May 1, 1982·Antimicrobial Agents and Chemotherapy·C Le Bouguenec, T Horodniceanu
Apr 1, 1981·Archives of Internal Medicine·D M ShlaesE Wolinsky

❮ Previous
Next ❯

Citations

Jan 1, 1996·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·F BiavascoP E Varaldo
Feb 1, 1990·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·D B Clewell
Feb 1, 1990·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·D M Shlaes, B Binczewski
Feb 1, 1990·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·G M Eliopoulos, C T Eliopoulos
Jan 1, 1991·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·H F GuiotF W Sebens
Nov 1, 1989·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·P E Reynolds
Feb 1, 1994·Diagnostic Microbiology and Infectious Disease·C A O'DonovanR H Eng
Nov 5, 2003·International Journal of Food Microbiology·Pier Sandro CocconcelliSimona Gazzola
Dec 16, 1998·International Journal of Food Microbiology·S SalminenT Mattila-Sandholm
Jun 5, 1999·International Journal of Food Microbiology·C M FranzM E Stiles
Jul 1, 1996·Diagnostic Microbiology and Infectious Disease·H F BonillaM J Zervos
Dec 1, 1989·Epidemiology and Infection·R C George, A H Uttley
Oct 1, 1996·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·R MatoA Tomasz
Apr 1, 1997·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·J Grissom-ArnoldS R Jaskunas
Aug 4, 1999·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·H de LencastreA Tomasz
Jun 27, 2000·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·G S SimonsenA Sundsfjord
Feb 1, 1995·Journal of Clinical Pharmacy and Therapeutics·S Murphy, R J Pinney
Jul 1, 1989·Antimicrobial Agents and Chemotherapy·T I NicasN E Allen
Sep 1, 1989·Antimicrobial Agents and Chemotherapy·T I NicasR Nagarajan
Sep 1, 1989·Antimicrobial Agents and Chemotherapy·D F SahmB Clarke
Oct 1, 1990·Antimicrobial Agents and Chemotherapy·S Dutka-MalenP Courvalin
Dec 1, 1990·Antimicrobial Agents and Chemotherapy·P Courvalin
Feb 1, 1990·Antimicrobial Agents and Chemotherapy·S al-ObeidL Gutmann
Feb 1, 1990·Antimicrobial Agents and Chemotherapy·S HandwergerA Kolokathis
Sep 1, 1990·Antimicrobial Agents and Chemotherapy·D F Sahm, L Olsen
Jan 1, 1991·Antimicrobial Agents and Chemotherapy·D J Herman, D N Gerding
Jan 1, 1992·Antimicrobial Agents and Chemotherapy·L GutmannJ van Heijenoort
Oct 1, 1992·Antimicrobial Agents and Chemotherapy·C C JohnsonM E Levison
Apr 1, 1992·Antimicrobial Agents and Chemotherapy·L J ZarlengaD F Sahm
Jul 1, 1992·Antimicrobial Agents and Chemotherapy·S VincentD M Shlaes
Jul 1, 1992·Antimicrobial Agents and Chemotherapy·D Billot-KleinJ van Heijenoort
Nov 1, 1993·Antimicrobial Agents and Chemotherapy·N C ClarkF C Tenover
Aug 1, 1993·Antimicrobial Agents and Chemotherapy·M Arthur, P Courvalin

❮ Previous
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