PMID: 9179919May 1, 1997Paper

Inducible (type II) nitric oxide synthase in human placental villous tissue of normotensive, pre-eclamptic and intrauterine growth-restricted pregnancies

Placenta
L MyattF Lyall

Abstract

We have utilized two distinct monospecific antibodies against the type II (macrophage or inducible) nitric oxide synthase (NOS) isoform to localize the distribution of the enzyme within the human placenta in tissues from normotensive pregnancies and those complicated by pre-eclampsia and/or intrauterine growth restriction. Both antibodies immunolocalize to cells in the villous stroma on frozen sections of villous tissue. Colocalization studies with anti-CD14 or anti-CD45 antibodies that recognize cells of leucocyte or monocyte/macrophage lineage indicate that Hofbauer cells are expressing type II NOS. This is in contrast to expression of type III (endothelial) NOS which is seen in syncytiotrophoblast and in villous vascular endothelium. In some, but not all, normotensive and pathologic placental tissue, some type II NOS immunostaining could be seen in syncytiotrophoblast and vascular endothelium; however, no differences could be discerned between groups of tissues. Expression of type II NOS by Hofbauer cells may indicate they are involved in surveillance against maternal immune insult or maternal pathogens whereby they secrete nitric oxide to exert a cytostatic/cytotoxic effect.

References

Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·C J LowensteinS H Snyder
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M W RadomskiS Moncada
Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J S PollockF Murad
Feb 1, 1991·American Journal of Obstetrics and Gynecology·L MyattD E Brockman
Jun 15, 1989·Biochemical and Biophysical Research Communications·D J StuehrC F Nathan
Jan 16, 1989·Biochemical and Biophysical Research Communications·R M Palmer, S Moncada
Oct 1, 1987·American Journal of Obstetrics and Gynecology·L M McCowanK Ritchie
Jan 1, 1985·British Journal of Obstetrics and Gynaecology·W B GilesP J Baird
Apr 1, 1967·The Journal of Pathology and Bacteriology·H Fox
Oct 1, 1982·Analytical Biochemistry·L C GreenS R Tannenbaum
Jun 1, 1994·Archives of Biochemistry and Biophysics·E P GarveyI G Charles
Sep 1, 1995·British Journal of Obstetrics and Gynaecology·N H MorrisP J Steer
Sep 1, 1995·American Journal of Obstetrics and Gynecology·F LyallI A Greer
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·D A GellerT R Billiar
Oct 1, 1993·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·K P ConradA K Davis
May 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·G SchönfelderM Paul

❮ Previous
Next ❯

Citations

Jan 28, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Aikaterini VaranouMyriam Hemberger
Jul 13, 2004·Histochemistry and Cell Biology·Leslie Myatt, Xiaolan Cui
Jul 14, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·J DötschW Rascher
Nov 14, 1997·American Journal of Reproductive Immunology : AJRI·A L EisL Myatt
Mar 25, 2014·Tissue & Cell·M IshiokaH Watanabe
Aug 15, 2002·Nitric Oxide : Biology and Chemistry·Ann SchwentkerTimothy R Billiar
Oct 15, 2003·Burns : Journal of the International Society for Burn Injuries·Andrew Rawlingson
Sep 18, 2002·Journal of Dermatological Science·Young-Jin LimDong-Sup Lee
Aug 23, 2001·International Immunopharmacology·P ForsytheA D Befus
Jan 11, 2003·British Journal of Pharmacology·Tsugunobu Andoh, Yasushi Kuraishi
Mar 5, 2015·International Journal of Molecular Sciences·Keiichi MatsubaraAkihiro Nawa
Dec 19, 2006·Taiwanese Journal of Obstetrics & Gynecology·Tai-Ho Hung, Graham J Burton
Dec 22, 1999·The Journal of Physiology·S R BartlettR Poston
Oct 15, 2008·Placenta·R P WebsterL Myatt
Dec 1, 2010·The Journal of Obstetrics and Gynaecology Research·Neerja RaniRani Kumar
Mar 22, 2003·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Andrea G WitlinChandra Yallampalli
Oct 24, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Luci Maria DusseKarina Braga Gomes
Oct 22, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Azize Yasemin Goksu ErolSevda Elis Yildiz
Jul 30, 2011·Placenta·B J KrauseP Casanello
Oct 2, 2008·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Stefano R GiannubiloAndrea L Tranquilli
May 14, 2009·Reproductive Sciences·Basky ThilaganathanJoanna Sheldon
Jun 29, 2017·Journal of Cellular Biochemistry·Jimena S BeltrameMaría L Ribeiro
Aug 21, 2013·Hypertension·Kim M HolwerdaA Titia Lely
Jun 21, 2015·Amino Acids·Asma KhalilPat O Brien
Jan 10, 2003·The Journal of Clinical Endocrinology and Metabolism·E KarterisD K Grammatopoulos
Apr 17, 2003·The Journal of Obstetrics and Gynaecology Research·Kazuo AsagiriTakafumi Kudo
Oct 20, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J L CookS T Davidge

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.