Inducing cells to disperse nickel nanowires via integrin-mediated responses

Nanotechnology
Anirudh SharmaBethanie J H Stadler

Abstract

We present non-cytotoxic, magnetic, Arg-Gly-Asp (RGD)-functionalized nickel nanowires (RGD-nanowires) that trigger specific cellular responses via integrin transmembrane receptors, resulting in dispersal of the nanowires. Time-lapse fluorescence and phase contrast microscopy showed that dispersal of 3 μm long nanowire increased by a factor of 1.54 with functionalization by RGD, compared to polyethylene glycol (PEG), through integrin-specific binding, internalization and proliferation in osteosarcoma cells. Further, a 35.5% increase in cell density was observed in the presence of RGD-nanowires, compared to an increase of only 15.6% with PEG-nanowires. These results promise to advance applications of magnetic nanoparticles in drug delivery, hyperthermia, and cell separation where uniformity and high efficiency in cell targeting is desirable.

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Citations

Oct 19, 2016·Chemical Communications : Chem Comm·Daniel ShoreBethanie J H Stadler
Dec 29, 2017·Materials·Stefan SchrittwieserJoerg Schotter
Jul 10, 2019·Nanoscale·Daniel ShoreBethanie J H Stadler
Mar 14, 2020·Journal of Nanobiotechnology·Aldo Isaac Martínez-BanderasJürgen Kosel
Aug 15, 2018·Sensors·Bethanie J H StadlerAnirudh Sharma
Aug 16, 2019·Materials·Alexander P SafronovGalina V Kurlyandskaya
Mar 17, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ruchika GoyalVibin Ramakrishnan
Jul 8, 2021·The Journal of Physical Chemistry. B·Mohammad Reza Zamani KouhpanjiBethanie Stadler
Sep 22, 2021·Physical Chemistry Chemical Physics : PCCP·Jiushuai DengChul B Park

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