Inducing death in tumor cells: roles of the inhibitor of apoptosis proteins

F1000Research
Darren FinlayKristiina Vuori

Abstract

The heterogeneous group of diseases collectively termed cancer results not just from aberrant cellular proliferation but also from a lack of accompanying homeostatic cell death. Indeed, cancer cells regularly acquire resistance to programmed cell death, or apoptosis, which not only supports cancer progression but also leads to resistance to therapeutic agents. Thus, various approaches have been undertaken in order to induce apoptosis in tumor cells for therapeutic purposes. Here, we will focus our discussion on agents that directly affect the apoptotic machinery itself rather than on drugs that induce apoptosis in tumor cells indirectly, such as by DNA damage or kinase dependency inhibition. As the roles of the Bcl-2 family have been extensively studied and reviewed recently, we will focus in this review specifically on the inhibitor of apoptosis protein (IAP) family. IAPs are a disparate group of proteins that all contain a baculovirus IAP repeat domain, which is important for the inhibition of apoptosis in some, but not all, family members. We describe each of the family members with respect to their structural and functional similarities and differences and their respective roles in cancer. Finally, we also review the curren...Continue Reading

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Citations

Mar 6, 2019·British Journal of Haematology·Prajwal BodduNaveen Pemmaraju
Aug 6, 2019·Advanced Pharmaceutical Bulletin·Rehmat Jan, Gul-E-Saba Chaudhry
Sep 10, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Hye-Jeong KwonSung-Dae Cho
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Jul 18, 2019·Molecular Therapy Oncolytics·Weike LiMing Luo
Jan 31, 2020·European Journal of Pharmacology·Chie IshikawaNaoki Mori

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Methods Mentioned

BETA
SMA
ubiquitination
xenograft
nuclear magnetic resonance
transgenic

Clinical Trials Mentioned

NCT01681368
NCT01188499
NCT02147873
NCT01940172
NCT02587962
NCT01098838
NCT01617668
NCT01955434
NCT02022098
NCT02503423

Software Mentioned

Astex

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