Inducing mesenchymal stem cell attachment on non-cell adhesive hydrogels through click chemistry.

Chemical Communications : Chem Comm
Alessia BattigelliAnita Shukla

Abstract

We introduce an innovative approach to adhere mesenchymal stem cells (MSCs) to a hydrogel scaffold by nucleating adhesion through strain-promoted click chemistry. This method yields a significant increase in cell viability compared to non-functionalized and RGD peptide functionalized hydrogels, providing a promising alternative to traditional biomaterials cell attachment approaches.

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Citations

Feb 3, 2022·Bioconjugate Chemistry·Alessia BattigelliAnita Shukla

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Methods Mentioned

BETA
protein folding
NMR
fluorescence
flow cytometry
fluorescence microscopy
Confocal microscopy

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