Inducing oral immune regulation of hepatitis B virus envelope proteins suppresses the growth of hepatocellular carcinoma in mice

Cancer
I GotsmanY Ilan

Abstract

Hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) expresses hepatitis B surface antigen (HBsAg) on its cell surface, and this may serve as a tumor-associated antigen. It was shown previously that adoptive transfer of immunity against HBsAg facilitates the suppression of experimental human HCC-expressing HBsAg in athymic mice. The authors recently showed that it was possible to augment the anti-HBV immune response through induction of oral immune regulation for HBV-associated antigens. The objective of this study was to evaluate the effect of oral immune regulation for HBV antigens on the growth of HBsAg-expressing HCC. Recipient athymic Balb/c mice were irradiated sublethally and injected with 10(7) human hepatoma cells followed by the adoptive transfer of 2 x 10(6) splenocytes from donor mice. Four groups of donor Balb/c mice were studied: Two groups were immune modulated through oral administration of HBV antigens (HBsAg, PreS1, and Pre S2) or bovine serum albumin (BSA). Two control groups were immunized for HBsAg and fed HBV antigens or BSA. Recipient mice were followed for tumor volume and serum alpha-fetoprotein (aFP) levels. The humoral immune response was determined by measuring serum HBs antibodies. HBV ...Continue Reading

References

Aug 1, 1992·Lancet·G M DusheikoA K Burroughs
Jan 1, 1988·Virchows Archiv. A, Pathological Anatomy and Histopathology·D ShouvalD A Shafritz
Jan 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K OkudaK Ohnishi
Jan 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E R DicksonR H Wiesner
Jan 1, 1995·Annual Review of Immunology·F V Chisari, C Ferrari
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·H L Weiner
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·L G GuidottiF V Chisari
Aug 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y IlanD Shouval
Jun 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D ShouvalY Ilan
Apr 1, 1996·The Journal of Clinical Investigation·B RehermannF V Chisari
Mar 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·Y IlanM S Horwitz
Oct 27, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y IlanJ Roy-Chowdhury
May 13, 1998·Immunology Today·S Strobel, A M Mowat
May 15, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y IlanJ R Chowdhury
Mar 3, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S TropY Ilan
Jun 1, 1999·Seminars in Liver Disease·Y IlanN R Chowdhury
Jul 28, 1999·Seminars in Liver Disease·M J Koziel
Oct 28, 1999·Archives of Pathology & Laboratory Medicine·D H Persing, F G Prendergast
Nov 24, 1999·Immunology Today·S J McSorley, P Garside
Nov 30, 1999·Immunology Today·U Chattopadhyay
Feb 3, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F RahmanH F Löhr
Mar 8, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A NaglerY Ilan
Apr 14, 2000·The American Journal of Gastroenterology·Y IlanE Goldin
Apr 19, 2000·The Journal of Experimental Medicine·B Rehermann
Aug 1, 2000·Virology·L G Guidotti, F V Chisari
Oct 26, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N WongP J Johnson

❮ Previous
Next ❯

Citations

Feb 19, 2010·Archivum Immunologiae Et Therapiae Experimentalis·Józef KapustaAndrzej Płucienniczak
Jul 24, 2015·Hepatology International·Yaron Ilan
Aug 4, 2004·Liver International : Official Journal of the International Association for the Study of the Liver·Eran IsraeliYaron Ilan
Jun 12, 2003·International Journal of Cancer. Journal International Du Cancer·Oren ShiboletYaron Ilan
Jun 5, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A NaglerY Ilan
Mar 12, 2005·World Journal of Gastroenterology : WJG·Kai LiuBing-Jun Lei
Sep 2, 2006·Journal of Leukocyte Biology·Anuradha Budhu, Xin Wei Wang
Apr 20, 2019·Clinical and Experimental Pharmacology & Physiology·Meric A Altinozİlhan Elmaci
Mar 2, 2011·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Eder Lilia Romero, Maria Jose Morilla

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.