Inducing sustained release and improving oral bioavailability of curcumin via chitosan derivatives-coated liposomes

International Journal of Biological Macromolecules
Mei-Ping TianXi-Guang Chen

Abstract

Liposomes (LPs), a delivery vehicle for stabilizing drugs, the characteristics of being easy to aggregate and fuse limit its application. Polymer coating is a promising way to tackle these issues. In this study, the potential of carboxymethyl chitosan (CMCS) and quaternary ammonium chitosan (TMC)-coated liposomes (CMCS/TMC-LPs) for improving the oral delivery capacity of curcumin (CUR) was explored. CMCS/TMC-LPs were prepared by electrostatic adsorption in a layer-by-layer manner. CMCS/TMC-LPs were spherical and had not obvious change in particle size and morphology after storage at 4 °C for 7 and 14 days. CMCS/TMC-LPs possessed favorable gastric acid tolerance (the cumulative drug release rate <10%) due to stable structure. The hemolysis test and Cell Counting Kit-8 (CCK8) assay appeared satisfactory biocompatibility of CMCS/TMC-LPs. The pharmacokinetics exhibited that oral absolute bioavailability of CUR loaded CMCS/TMC-LPs was about 38%, which was around 6 folds and 3 folds higher than CUR loaded LPs and CUR loaded TMC-LPs, respectively. The in vivo experiments showed that CMCS/TMC-LPs could prolong the retention time of CUR in systemic circulation and generate high level of CUR in liver, spleen and lung. Thus, CMCS/TMC-LPs ...Continue Reading

References

Feb 15, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Lev Bromberg, Valery Alakhov
Dec 24, 2005·Critical Reviews in Food Science and Nutrition·T Matthew TaylorJochen Weiss
Aug 27, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Yuuka Fukui, Keiji Fujimoto
Oct 20, 2011·Journal of Liposome Research·Huanlei ChenGuangxi Zhai
Aug 9, 2012·Molecular Pharmaceutics·Sanyog JainAshish K Agrawal
Sep 27, 2012·Colloids and Surfaces. B, Biointerfaces·Najeh Maissar KhalilRubiana Mara Mainardes
May 15, 2013·Colloids and Surfaces. B, Biointerfaces·Anna KarewiczMaria Nowakowska
Dec 10, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Chao FengXiguang Chen
Mar 15, 2015·Colloids and Surfaces. B, Biointerfaces·Chao FengXi Guang Chen
Dec 19, 2016·Carbohydrate Polymers·Abhijeet D KulkarniChandrakantsing V Pardeshi
Apr 11, 2019·Polymers·Twana Mohammed M WaysVitaliy V Khutoryanskiy

❮ Previous
Next ❯

Citations

Sep 16, 2020·International Journal of Molecular Sciences·Angela FabianoYlenia Zambito
Feb 5, 2021·Advanced Drug Delivery Reviews·S G AntimisiarisS Mourtas
Jul 31, 2020·Nanomedicine : Nanotechnology, Biology, and Medicine·Wenjun WangHuiling Hu
May 1, 2021·Pharmaceutics·Andreea Teodora IacobLenuta Profire
Apr 24, 2021·Drug Discovery Today·Anna E CaprificoGianpiero Calabrese
May 25, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Apratim JashSyed S H Rizvi
Jun 5, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mengjie SunYa Liu
Jul 17, 2021·Nanomedicine·Eric MühlbergPhilipp Uhl
Aug 14, 2020·Current Pharmaceutical Design·Honey GoelKamalinder K Singh
Oct 2, 2021·AAPS PharmSciTech·Mumuni SumailaYahya E Choonara

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.