Induction and Expression of Fear Sensitization Caused by Acute Traumatic Stress

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Jennifer N PerusiniMichael S Fanselow

Abstract

Fear promotes adaptive responses to threats. However, when the level of fear is not proportional to the level of threat, maladaptive fear-related behaviors characteristic of anxiety disorders result. Post-traumatic stress disorder develops in response to a traumatic event, and patients often show sensitized reactions to mild stressors associated with the trauma. Stress-enhanced fear learning (SEFL) is a rodent model of this sensitized responding, in which exposure to a 15-shock stressor nonassociatively enhances subsequent fear conditioning training with only a single trial. We examined the role of corticosterone (CORT) in SEFL. Administration of the CORT synthesis blocker metyrapone prior to the stressor, but not at time points after, attenuated SEFL. Moreover, CORT co-administered with metyrapone rescued SEFL. However, CORT alone without the stressor was not sufficient to produce SEFL. In these same animals, we then looked for correlates of SEFL in terms of changes in excitatory receptor expression. Western blot analysis of the basolateral amygdala (BLA) revealed an increase in the GluA1 AMPA receptor subunit that correlated with SEFL. Thus, CORT is permissive to trauma-induced changes in BLA function.

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Citations

Jul 6, 2016·Frontiers in Computational Neuroscience·Luca Puviani, Sidita Rama
Jan 20, 2017·Neuron·Marco PignatelliAntonello Bonci
Dec 15, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kerry J Ressler, Jordan W Smoller
Jun 14, 2018·Genes, Brain, and Behavior·Alexei Morozov, Wataru Ito
Mar 14, 2019·Hippocampus·Timothy J SchoenfeldHeather A Cameron
Jun 5, 2019·Stress : the International Journal on the Biology of Stress·Marlene A WilsonFrancis G Spinale
Dec 4, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Zachary T PenningtonMichael S Fanselow
Jun 4, 2019·Frontiers in Behavioral Neuroscience·Michael A Conoscenti, Michael S Fanselow
Jun 19, 2016·Learning & Memory·Andrew M PoulosMichael S Fanselow
Sep 17, 2016·Learning & Memory·Ashley M BlouinCourtney A Miller
May 11, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Michael R Drew, Kylie A Huckleberry
Apr 4, 2019·Frontiers in Neuroscience·Sarah HersmanMichael S Fanselow
Dec 17, 2020·Frontiers in Neurology·Ann N HoffmanMichael S Fanselow
Oct 20, 2020·Neurobiology of Learning and Memory·Nicolette A MoyaBenjamin N Greenwood
May 27, 2021·Neurobiology of Stress·Sarah T GonzalezMichael S Fanselow
Jul 6, 2021·Frontiers in Behavioral Neuroscience·Amanda S Russo, Ryan G Parsons

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