Induction and expression of human cartilage glycoprotein 39 in rheumatoid inflammatory and peripheral blood monocyte-derived macrophages

Experimental Cell Research
R B KirkpatrickM Rosenberg

Abstract

Human cartilage glycoprotein 39 (HC gp-39) has been described as a major secreted product of cultured articular chondrocytes, synovial fibroblasts, and the osteosarcoma line MG63. However, its expression in these cells types has not been directly linked to corresponding cell types in vivo. In this report, expression of HC gp-39 is demonstrated from peripheral blood-derived macrophages in association with their differentiation from monocytes to macrophages. Consistent with macrophage specificity, HC gp-39 expression is also induced upon selective stimulation of the pluripotent promyelocytic leukemia cell line HL-60 toward the monocyte/macrophage lineage with vitamin D3 or phorbol 12-myristate 13-acetate (PMA), while treatments stimulating granulocyte and eosinophilic pathways do not induce expression. Furthermore, HC gp-39 expression levels correlate with the degree of morphological differentiation induced by PMA and vitamin D3 treatments. PMA-induced mRNA expression occurs by 36 h and is a secondary transcriptional response since its synthesis is inhibited by cycloheximide. Apparently, HC gp-39 expression is tied to later events in the differentiation of monocytes into macrophages. The in vivo significance of these results is v...Continue Reading

Citations

May 22, 2010·Journal of Neurotrauma·Dafna Bonneh-BarkayAmy K Wagner
Oct 18, 2000·Rheumatology·E ZanelliR R de Vries
Aug 26, 2006·European Journal of Haematology·Anne K MylinUNKNOWN Nordic Myeloma Study Group
Jan 8, 2008·Arthritis Research & Therapy·Raimund W KinneGerd-R Burmester
Nov 30, 2000·Arthritis Research·R W KinneG R Burmester
Oct 2, 2009·Future Oncology·Julia S JohansenBenny V Jensen
Aug 18, 2010·Marine Drugs·Feisal Khoushab, Montarop Yamabhai
Jan 13, 2015·Leukemia & Lymphoma·Anne K MylinUNKNOWN Nordic Myeloma Study Group
Nov 13, 2008·Critical Reviews in Clinical Laboratory Sciences·Frederick D Coffman
Dec 1, 2001·Scandinavian Journal of Rheumatology·J S JohansenM Sharif
Jan 18, 2007·Expert Opinion on Therapeutic Targets·Julia S JohansenPaul A Price
May 9, 2014·Disease Markers·Maria MusumeciSalvatore Musumeci
Nov 12, 2005·Critical Reviews in Clinical Laboratory Sciences·Leonardo PunziMario Plebani
Apr 15, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Nanna JunkerPaul E G Kristjansen
Mar 22, 2000·Electrophoresis·M Boussac, J Garin
Jan 1, 2000·Arthritis and Rheumatism·J S JohansenP A Price
Mar 10, 2011·The Journal of Biological Chemistry·Ralph A FrancesconeRong Shao
Jul 19, 2018·Annals of Clinical Biochemistry·Ming-Zhu GaoTing-Wang Jiang
Jan 24, 2007·Journal of Molecular Histology·Merete RingsholtLise H Christensen
Dec 30, 2006·Clinical Orthopaedics and Related Research·G TrudelO Laneuville
Aug 30, 2007·Journal of Gastroenterology and Hepatology·Yusuf ErzinAykut Ferhat Celik
Jan 25, 2008·Environmental Toxicology·Hyun-Mi SongChoon-Sik Park
Feb 7, 2009·Shock·Noriyuki HattoriHiroyuki Hirasawa
Apr 3, 1999·British Journal of Cancer·C CintinH J Nielsen
Oct 24, 2006·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·E U SumerP Qvist
Mar 28, 2012·Rheumatology International·Maria KazakovaVictoria Sarafian
Jan 2, 2004·Aging Clinical and Experimental Research·Leonardo PunziSilvano Todesco
Apr 5, 2016·The Journal of Medical Investigation : JMI·Masanari WatanabeEiji Shimizu
Sep 23, 2003·Clinical Chemistry·Daniela BernardiMario Plebani
Apr 12, 2001·The Journal of Biological Chemistry·N C ChangA C Chang
Mar 30, 2001·The Journal of Biological Chemistry·Y J SunC D Hsiao
Apr 24, 2003·The Journal of Biological Chemistry·Mireille Lafon-CazalPhilippe Marin

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