PMID: 591061Dec 1, 1977

Induction and expression of immunity after BCG immunization

Infection and Immunity
M J Lefford

Abstract

The induction and expression of immunity to Mycobacterium tuberculosis after BCG immunization by intravenous, subcutaneous, and pulmonary routes has been investigated in mice. The speed with which protective immunity was engendered was a function of inoculum size; the immunization route was a less influential factor. Tuberculin hypersensitivity varied both with the inoculim size and immunization route, being least after pulmonary immunization. Once immunity was established, a steady state ensued in which the number of sensitized lymphocytes in the spleen was similar, regardless of the route or dose of vaccination. Actively immunized animals controlled intravenous and subcutaneous challenge infections, regardless of the method of vaccination. However, pulmonary challenge was resisted most efficiently by mice immunized by the pulmonary route. Adoptive immunity was well expressed in the spleen only, but the lungs were no more deficient in this regard than the footpad. It is suggested that enhanced immunity in the lungs depends on a population of resident sensitized lymphocytes.

Citations

Dec 1, 1983·New Zealand Veterinary Journal·G W de LisleN R Gladden
Apr 6, 2007·Expert Review of Vaccines·Dongmei Lu, Anthony J Hickey
Jul 6, 2010·European Journal of Immunology·Lisa M ConnorJoanna R Kirman
Apr 16, 2014·Infection and Immunity·Flavia L Ribeiro-GomesNathan C Peters
Dec 1, 1983·The Journal of Pathology·M J RidleyD A Willoughby
Aug 1, 1981·British Journal of Haematology·G Marchal, G Milon
Jul 23, 2005·Viral Immunology·Michael SantosuossoZhou Xing
Jan 1, 1982·The Journal of Pathology·W G SpectorM J Ridley

Related Concepts

BCG Vaccine
Delayed Hypersensitivity
Active Immune Response
Cellular Immune Response
Neonatal Immunity, Maternally-Acquired
Lymphoid Cells
Spleen
Tuberculosis

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