Induction and inhibition of preferential enrichment by controlling the mode of the polymorphic transition with seed crystals

Chemistry : a European Journal
Rui TamuraHirohito Tsue

Abstract

Both induction and inhibition of "preferential enrichment", an unusual symmetry-breaking enantiomeric-resolution phenomenon observed upon simple recrystallization of a certain kind of racemic crystals from organic solvents, have been successfully achieved by controlling the mode of the polymorphic transition during crystallization with appropriate seed crystals. Such control of the polymorphic transition can be interpreted in terms of a novel phenomenon consisting of 1) the adsorption of prenucleation aggregates, 2) the heterogeneous nucleation and crystal growth of a metastable crystalline form, and 3) the subsequent polymorphic transition into the more stable form; these three processes occur on the same surface of a seed crystal. We refer to this phenomenon as an "epitaxial transition", which has been confirmed by means of in situ attenuated total reflection (ATR) FTIR spectroscopy in solution and the solid state, differential scanning calorimetry (DSC) measurements of the deposited crystals, and X-ray crystallographic analysis of the single crystals or the direct-space approach employing the Monte Carlo method with the Rietveld refinement for the structure solution from the powder X-ray diffraction data.

References

Dec 22, 1999·Angewandte Chemie·J BernsteinJ O Henck
May 16, 2001·Angewandte Chemie·Kenneth D. M. HarrisBenson M. Kariuki
Jul 4, 2001·Enantiomer·H TakahashiT Ushio
Oct 19, 2001·Biophysical Journal·H RapaportL Leiserowitz
Nov 1, 2001·Journal of the American Chemical Society·C A MitchellM D Ward
Jun 6, 2002·Journal of the American Chemical Society·J Narasimha MoorthyP Venugopalan
Jul 18, 2002·Accounts of Chemical Research·Gautam R Desiraju
Jul 19, 2002·Chemical Communications : Chem Comm·Colin C Seaton, Maryjane Tremayne
Dec 15, 2004·Biophysical Journal·Inna SolomonovLeslie Leiserowitz

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Citations

Mar 18, 2008·Drug Discovery Today·Antonio Llinàs, Jonathan M Goodman
Aug 11, 2016·Physical Chemistry Chemical Physics : PCCP·Mrinal GhoshArun Kanti Sikder

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