PMID: 9446838Mar 7, 1998Paper

Induction and modulation of acute-phase response by protein malnutrition in rats: comparative effect of systemic and localized inflammation on interleukin-6 and acute-phase protein synthesis

The Journal of Nutrition
S LyoumiJ P Lebreton

Abstract

The acute-phase protein (APP) response is regulated by cytokines such as interleukin-6 (IL-6), interleukin-1 (IL-1) and tumor necrosis factor (TNF), but may also be influenced by malnutrition. The aims of this study were as follows: 1) to determine in rats the effect of a protein-deficient diet on IL-6 mRNA expression in intestine, liver and peripheral blood mononuclear cells (PBMC), and on alpha-1 acid glycoprotein (AGP) and alpha-2 macroglobulin (A2M) serum levels and hepatic mRNA expression; 2) to compare, in protein-deficient rats, the IL-6 and APP responses after a turpentine (TO)- or a lipopolysaccharide (LPS)-induced inflammation; and 3) to determine the effect of a protein malnutrition on IL-6 mRNA expression in rat PBMC treated ex vivo with LPS. Interleukin-6 mRNA was present in intestine and PBMC but not in the liver of malnourished rats, and was absent in any tissue or cells of controls. A2M was present in the serum from malnourished rats but not after refeeding. AGP mRNA expression was not influenced by protein malnutrition. In malnourished rats, IL-6 serum level peaked later than in controls after TO and LPS treatment. In malnourished TO-treated rats, A2M mRNA increased earlier than in controls and remained detecta...Continue Reading

References

Jan 1, 1990·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·K ShirotaS Jothy
Oct 1, 1986·The American Journal of Clinical Nutrition·C A KauffmanM J Kluger
Oct 1, 1988·European Journal of Immunology·M HelleL A Aarden
Oct 1, 1987·European Journal of Immunology·L A AardenP M Lansdorp
Jun 1, 1981·The American Journal of Clinical Nutrition·L Hoffman-GoetzG L Blackburn
Nov 1, 1994·JPEN. Journal of Parenteral and Enteral Nutrition·G Jennings, M Elia
Oct 1, 1994·The Journal of Experimental Medicine·E FattoriV Poli
Dec 1, 1993·Journal of Clinical Pathology·S C JonesJ T Whicher
Feb 1, 1993·Clinical Science·J F DohertyK P McAdam
Jan 1, 1993·Clinical Immunology and Immunopathology·R P McCabeM G Peters

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Citations

Mar 11, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·A ArtlE Malle
Nov 20, 2003·American Journal of Physiology. Endocrinology and Metabolism·Nilima Raina, Khursheed N Jeejeebhoy
Aug 22, 2008·Journal of Veterinary Science·Eun Joo KimKyoung Ho Choi
Mar 26, 2009·Current Opinion in Clinical Nutrition and Metabolic Care·Rubens FeferbaumClaudio Leone
Jul 17, 2013·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Shari E SmithPhyllis G Paterson
Jan 1, 2012·Biomarkers in Cancer·Faiz-Ul-Hassan Nasim Attiq-Ur-Rehman
Nov 6, 2008·American Journal of Physiology. Endocrinology and Metabolism·Nabile BoukhettalaMoïse Coëffier
Jul 16, 2014·Journal of Pediatric Gastroenterology and Nutrition·Cristina O MargineanCarmen Duicu
Apr 29, 1999·Clinical Chemistry and Laboratory Medicine : CCLM·A M Johnson
Oct 23, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·A A JacksonF Jahoor
Nov 30, 2014·BMC Complementary and Alternative Medicine·Mohamed Mohamed SolimanTamer Ahmed Ismail
Sep 22, 2018·Annals of Gastroenterological Surgery·Takayuki ShimizuKeiichi Kubota
Jun 28, 2000·Current Opinion in Clinical Nutrition and Metabolic Care·V E BaracosO A Adegoke
Aug 30, 2008·Nutrition Reviews·Richard L GuerrantAldo A M Lima
Feb 13, 2001·Cytokine·M CoëffierP Déchelotte
Jun 6, 2000·Biochimica Et Biophysica Acta·C Malpuech-BrugèreY Rayssiguier
Mar 15, 2003·Biochimica Et Biophysica Acta·Ryuji BitoHiroaki Kawabata
Feb 22, 2008·Kidney International·D S C RajA Ferrando

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