PMID: 6171825Nov 1, 1981Paper

Induction by cholera toxin of synchronous divisions in vivo in the epidermis resulting in hyperplasia

Proceedings of the National Academy of Sciences of the United States of America
T Kuroki

Abstract

Intracutaneous injection of cholera toxin, exotoxin of Vibrio cholerae, into the dorsal skin of mice, rats, and hamsters at doses of greater than 0.1 ng evoked an acute reaction at the site of injection, which was characterized histologically by an edematous reaction in the dermis and mitotic stimulation in the epidermis. Mitotic and labeling induces of basal cells of the mouse epidermis showed two peaks at 24 and 48 hr after injection, thereby producing epidermal hyperplasia. The thickness of the intrafollicular epidermis increased progressively from 32 hr after toxin injection, being greatest on day 4 and decreasing to normal on day 7. The epidermis on day 4 after injection of 1.0 ng of toxin was about 4- to 6-fold thicker than normal or phosphate buffer-treated control skin. This sequence of events indicated that cholera toxin induced two successive synchronous divisions of the epidermal cells and produced temporary hyperplasia without interfering with epidermal differentiation. The complete structure and function of the cholera toxin are required for induction of epidermal hyperplasia: no mitotic stimulation was induced by injection of the A and B units of the cholera toxin molecule or by preincubation of the toxin with ant...Continue Reading

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Citations

Jan 1, 1984·Archives of Dermatological Research·D I RoseeuwJ J Voorhees
Oct 9, 1989·Biochimica Et Biophysica Acta·A PessinaC E Cocuzza
Mar 20, 1998·The Journal of Investigative Dermatology·K HanadaA Naganuma
Nov 1, 1983·Experimental Cell Research·P S Tong, C L Marcelo
Jul 1, 1989·Japanese Journal of Cancer Research : Gann·T Kuroki, Y Murakami
May 29, 1986·Biochemical and Biophysical Research Communications·T KurokiY Murakami
Apr 16, 1998·International Journal of Cancer. Journal International Du Cancer·T Kuroki, M F Rajewsky

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