Induction Chemotherapy Followed by Chemo-intensity-modulated Radiotherapy for Locally Advanced Nasopharyngeal Cancer.

Clinical Oncology : a Journal of the Royal College of Radiologists
A B MiahC M Nutting

Abstract

To determine the toxicity and tumour control rates after chemo-intensity-modulated radiotherapy (chemo-IMRT) for locally advanced nasopharyngeal cancers (LA-NPC). Patients with LA-NPC were enrolled in a trial to receive induction chemotherapy followed by parotid-sparing chemo-IMRT. The primary site and involved nodal levels received 65 Gy in 30 fractions and at risk nodal levels received 54 Gy in 30 fractions. Incidence of ≥grade 2 subjective xerostomia was the primary end point. Secondary end points included incidences of acute and late toxicities and survival outcomes. Forty-two patients with American Joint Committee on Cancer stages II (12%), III (26%) and IV (62%) (World Health Organization subtype: I [5%]; II [40%]; III [55%]) completed treatment between January 2006 and April 2010 with a median follow-up of 32 months. Incidences of ≥grade 2 acute toxicities were: dysphagia 83%; xerostomia 76%; mucositis 97%; pain 76%; fatigue 99% and ototoxicity 12%. At 12 months, ≥grade 2 subjective xerostomia was observed in 31%, ototoxicitiy in 13% and dysphagia in 4%. Two year locoregional control was 86.2% (95% confidence interval: 70.0-94.0) with 2 year progression-free survival at 78.4% (61.4-88.6) and 2 year overall survival at 85...Continue Reading

References

Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics·J D CoxT F Pajak
Jul 1, 1994·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·S M Bentzen
May 15, 2002·International Journal of Radiation Oncology, Biology, Physics·Nancy LeeKaren K Fu
Dec 14, 2004·International Journal of Radiation Oncology, Biology, Physics·Michael K M KamAnthony T C Chan
Jun 7, 2005·International Journal of Radiation Oncology, Biology, Physics·Suzanne L WoldenMichael J Zelefsky
Oct 11, 2005·International Journal of Radiation Oncology, Biology, Physics·Dora L W KwongGordon Au
Feb 20, 2007·Clinical Oncology : a Journal of the Royal College of Radiologists·S A BhideC M Nutting
Oct 18, 2007·International Journal of Radiation Oncology, Biology, Physics·Anne W M Lee
Nov 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael K M KamAnthony T C Chan
Jun 29, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A T C ChanUNKNOWN EHNS-ESMO-ESTRO Guidelines Working Group
Aug 14, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Sarah L GullifordChristopher M Nutting
Jan 23, 2013·Clinical Oncology : a Journal of the Royal College of Radiologists·R J ColacoL W Lee
Aug 21, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Ceri PowellChris M Nutting

❮ Previous
Next ❯

Citations

Oct 30, 2016·International Journal of Radiation Oncology, Biology, Physics·Jamie A DeanSarah L Gulliford
Feb 1, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Tingyu LiLijie Lv
Dec 10, 2019·Clinical Oncology : a Journal of the Royal College of Radiologists·F SlevinR Prestwich
Jan 7, 2017·Clinical Oncology : a Journal of the Royal College of Radiologists·J A DeanS L Gulliford

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.