Induction chemotherapy for locally advanced laryngeal and hypopharyngeal cancer: Single institution experience.

Head & Neck
Or DaganAron Popovtzer

Abstract

The role of induction chemotherapy (IC) in locally-advanced head and neck squamous cell carcinoma (LAHNSCC) is unclear. A retrospective study of 104 patients with LAHNSCC of the larynx and hypopharynx, treated with IC or up-front chemoradiotherapy (CRT). Eighty patients received CRT and 24 IC followed by CRT; median follow up was 51.33 months. IC significantly improved median overall survival (OS) in the hypopharyngeal cancer group (64.7 vs 21 months, P = .003); with significant difference in the proportion of complete response at first imaging assessment post definitive CRT; no significant difference in disease free survival (DFS), loco-regional or distant failure in the hypopharyngeal cancer group; or OS and DFS in the laryngeal cancer group. Patients with laryngeal cancer had significantly better median OS than those with hypopharyngeal cancer. IC significantly improved complete response rates after CRT, and improved outcomes for patients with locally advanced hypopharyngeal, not laryngeal, cancers.

References

Oct 1, 1989·Radiology·H D Curtin
Dec 1, 1994·Clinical Otolaryngology and Allied Sciences·A S JonesD G Husband
Dec 21, 2004·International Journal of Cancer. Journal International Du Cancer·André Lopes CarvalhoLuiz Paulo Kowalski
Oct 26, 2007·The New England Journal of Medicine·Jan B VermorkenUNKNOWN EORTC 24971/TAX 323 Study Group
Jan 31, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M R PosnerUNKNOWN TAX 324 Study Group
Apr 12, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J-L LefebvreUNKNOWN EORTC Head and Neck Cancer Group
Nov 28, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Arlene A ForastiereJay S Cooper
Nov 22, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R HittUNKNOWN Spanish Head and Neck Cancer Cooperative Group (TTCC)
Jul 23, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ezra E W CohenEverett E Vokes
Oct 21, 2014·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Dong Hyun KimDong Won Kim
Sep 16, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M G GhiUNKNOWN GSTTC (Gruppo di Studio Tumori della Testa e del Collo) Italian Study Group

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