Induction chemotherapy prior to surgery with or without postoperative radiotherapy for oral cavity cancer patients: Systematic review and meta-analysis

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Gustavo Nader MartaLuis Paulo Kowalski

Abstract

Locoregionally advanced oral cavity cancers are aggressive tumours with high risk of relapse after definitive treatment. This study was performed to assess the effectiveness and safety of induction chemotherapy prior to surgery for untreated oral cavity cancer patients. Only prospective phase III randomised studies comparing induction chemotherapy followed by surgery with or without postoperative radiotherapy (Chemo Group) compared with surgery with or without postoperative radiotherapy (Control Group) were eligible. Two of the authors independently selected and assessed the studies regarding eligibility criteria and risk of bias. Two studies were selected. A total of 451 patients were randomly assigned to Chemo Group (n=226) versus Control Group (n=225). Most patients had tumours at clinical stages III/IV (89.1%). Both trials were classified as having low risk of bias. No significant overall benefit in favour of induction chemotherapy was found regarding loco-regional recurrence, disease-free survival and overall survival. A subgroup analysis of individual data from cN2 patients showed statistically significant overall survival benefit in favour of induction chemotherapy. The included studies did not directly compare toxicity ...Continue Reading

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Citations

Nov 3, 2015·Oral Oncology·Gustavo Nader MartaLuiz Paulo Kowalski
Apr 11, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R I HaddadJ B Vermorken
Feb 10, 2018·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Thaís Bianca BrandãoAlan Roger Santos-Silva
Apr 28, 2020·Cancer Control : Journal of the Moffitt Cancer Center·Rajab AlzahraniMajed Alghamdi
Mar 21, 2020·Cancers of the Head & Neck·Margaret Stafford, John Kaczmar
Feb 6, 2018·Molecular and Clinical Oncology·Hiroshi YamazakiYoshihide Ota
Mar 16, 2019·Current Treatment Options in Oncology·David Kim, Ryan Li
Jun 7, 2019·BMJ : British Medical Journal·Pankaj ChaturvediSaman Warnakulasuriya
Jan 21, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Diogo SequeiraAlexandra R Fernandes
Jul 16, 2021·Clinical Oncology : a Journal of the Royal College of Radiologists·K ChiuA Hope
Jul 27, 2021·Journal of Chemotherapy·Abhenil Mittal, Atul Sharma
Aug 29, 2021·Current Oncology Reports·Thiago Bueno de OliveiraLuiz Paulo Kowalski
Sep 3, 2021·JAMA Otolaryngology-- Head & Neck Surgery·Razan MasarwyNidal Muhanna

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