Induction chemotherapy with carboplatin and taxol followed by radiotherapy and concurrent weekly carboplatin + taxol in locally advanced nasopharyngeal carcinoma

Cancer Chemotherapy and Pharmacology
Mario AiroldiCarlo Giordano

Abstract

Aim of this study was the clinical evaluation of carboplatin-taxol combination in a neoadjuvant and concomitant setting with conventional radiotherapy in loco-regionally advanced nasopharyngeal carcinoma (A-NPC). Thirty patients were treated with three cycles of carboplatin (AUC6) plus taxol (175 mg/m(2)) on day 1 every 3 weeks, followed by weekly carboplatin (AUC1) plus Taxol (60 mg/m2) and concomitant radiotherapy (70 Gy). We observed the objective complete response rates of 33% (after chemotherapy) and 87% (after chemo-radiotherapy). Treatment tolerability and toxicity were controllable. Three- and five-year progression-free survival were 80 and 75%, respectively, and 3- and 5-year overall survival were 85 and 80% (follow-up 49.5 months). Five-year loco-regional control was 90.3%, and five-year distant metastases-free survival was 85%. Neoadjuvant chemotherapy with such protocol represents a feasible, efficient treatment for patients with A-NPC, ensuring excellent loco-regional disease control and overall survival with low incidence of distant metastases.

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Citations

Sep 4, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Anne W M LeeT H Lam
Nov 5, 2015·International Journal of Radiation Oncology, Biology, Physics·Li-Ting LiuHai-Qiang Mai
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May 23, 2013·World Journal of Clinical Oncology·Francesco PerriFrancesco Caponigro
Nov 14, 2013·The Journal of Craniofacial Surgery·Paolo BoffanoGiancarlo Pecorari
Feb 3, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Neyran KertmenH Ibrahim Gullu

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