Abstract
Fifty-three patients with locally advanced squamous cell carcinoma of the head and neck (SCCHN) were treated with a combined modality treatment consisting of three cycles of induction chemotherapy before definitive surgery and/or radiotherapy. Two additional cycles of the same chemotherapy were given after local-regional therapy. The chemotherapeutic regimen included cisplatinum 100 mg/m2 on day 1, 5-fluorouracil 1000 mg/m2 as a continuous infusion on days 2-6, bleomycin 15 units i.m. on days 15 and 29, mitomycin C 4 mg/m2 i.v. on day 22 and hydroxyurea 1000 mg/m2 p.o. on days 23-27. Each cycle was repeated every 42 days. Forty-nine patients are evaluable for response. There were 37 men and 12 women, with a median age of 58 years (range 18-75 years) and performance status of 80 (range 40-90). Sixteen patients (33%) demonstrated a complete response, 20 (41%) a partial response, yielding a 74% response rate to induction chemotherapy; 12 (24%) patients had stable disease and 1 (2%) progressive disease. The actuarial survival of those patients who completed the whole treatment program was 65% at 2 years and 47% at 3 years. Toxicities included nausea and vomiting (66%). anemia (34%), leukocytopenia (54%), thrombocytopenia (22%), sto...Continue Reading
References
Jul 1, 1977·Cancer·O R MerinoG H Fletcher
Mar 15, 1986·Cancer·M SpauldingJ Lore
Aug 15, 1986·Cancer·M RahimaJ Sidi
Jan 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T J ErvinD A Schoenfeld
Sep 15, 1987·Cancer·M ClavelO Dalesio
Apr 15, 1988·Cancer·K S Sridhar, E Donnelly
Sep 15, 1987·Cancer·C JacobsW E Fee
Mar 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M GaspariniF Morandi
Apr 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·I TannockT Panzarella
Mar 1, 1986·European Journal of Cancer & Clinical Oncology·P DodionM Rozencweig
Mar 1, 1985·Cancer·M RooneyM Al-Sarraf
Nov 1, 1985·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K S DasmahapatraB F Rush
Nov 1, 1980·Cancer·J H GlickE Velez-Garcia
Jan 1, 1983·Cancer·D E SchullerA D James
Sep 1, 1984·Cancer·J F EnsleyM Al-Sarraf
Jan 1, 1984·Head & Neck Surgery·B VikramR Spiro
Oct 1, 1982·American Journal of Surgery·A WeaverM Al-Sarraf
Jan 1, 1982·The Journal of Surgical Research·S H LermanH S Ormsbee
Citations
Jul 12, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S JelićD Gavrilović
Mar 10, 2001·Cancer Treatment Reviews·W T Bradner
Sep 15, 1992·Cancer·K S SridharS P Richman
Oct 1, 1990·Cancer·G FountzilasA Tourkantonis