Induction in guinea-pigs of airway hyperreactivity and decreased lung beta-adrenoceptor number by 15-hydroperoxy-arachidonic acid

British Journal of Pharmacology
G FolkertsA J Van Oosterhout


Administration to guinea-pigs of 15-hydroperoxy-arachidonic acid (0.2 mg kg-1 i.p.) caused a 20% reduction of lung beta-adrenoceptor number. Furthermore, in vivo, a hyperreactivity of the airways to nebulized histamine was observed. In contrast, administration of 15-hydroxy-arachidonic acid (0.2 mg kg-1 i.p.) did not cause a significant change in either of these parameters.


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