Induction in mice of serum IgE levels after treatment with anti-mouse IgD antibodies is preceded by differential modulation of tissue cytokine gene transcription

European Journal of Immunology
F KricekG M Bahr

Abstract

Injection of mice with purified goat anti-mouse IgD (GAMD) leads to an interleukin (IL)-4-dependent increase of serum IgE levels. Challenge of GAMD-primed mice with goat IgG (GIG) initiates a secondary immune response with elevated serum IgE. In this report, kinetic cytokine transcript profiles of murine lymphoid tissues in response to primary i.v. GAMD treatment, as well as GIG challenge are presented. For the first time, gene transcription patterns of the recently described cytokines IL-12 and IL-13 are shown and compared with the corresponding patterns for other cytokine genes involved in IgE regulation, i.e. IL-4, and interferon (IFN)-gamma. After GAMD injection, two groups of induction profiles were observed in spleen, mesenteric lymph nodes and Peyer's patches: while IL-4 and IL-12p35 gene transcription was strongly enhanced, IFN-gamma, IL-12p40 and IL-13 mRNA were only moderately induced. Generally, maximal mRNA induction was measured on days 3 to 4 after GAMD treatment. The data demonstrate a clear-cut difference between the IL-4 and IL-13 response on the transcriptional level although both gene products show similar biological activities. The cytokine mRNA profiles support the assumption of IL-4 playing the central rol...Continue Reading

References

Aug 1, 1992·PCR Methods and Applications·F Ferre
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·K E NoonanI B Roninson
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J PèneJ Banchereau
Sep 1, 1988·The Journal of Experimental Medicine·D A Lebman, R L Coffman
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·F D FinkelmanW E Paul
Dec 1, 1974·The Journal of Experimental Medicine·A Kulczycki, H Metzger
Jun 4, 1984·Nature·H J LeibsonJ W Kappler
Feb 26, 1993·Journal of Immunological Methods·P C MelbyV V Tryon
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J PunnonenJ E de Vries
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·A N McKenzieS Menon
May 1, 1993·Immunology Today·G TrinchieriJ Chehimi

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