PMID: 7526298Jul 18, 1994Paper

Induction in the rat hippocampus of long-term potentiation (LTP) and long-term depression (LTD) in the presence of a nitric oxide synthase inhibitor

Neuroscience Letters
J A CummingsR C Malenka

Abstract

Several recent studies have suggested a critical role for nitric oxide (NO) production in hippocampal LTP and LTD. In this study we show that normal LTP and LTD can be induced in rat hippocampal slices incubated in the NO synthase inhibitor L-NG-nitroarginine (NOArg) (100 microM). A test of NMDA-stimulated cGMP production demonstrated that incubation of slices in 100 microM NOArg effectively inhibited NO synthase. Our results suggest that NO synthase activity may not be required for the generation of LTP or LTD in CA1 of rat hippocampus.

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Citations

Sep 1, 1995·Brain Research. Brain Research Reviews·J H Medina, I Izquierdo
Sep 1, 1996·Journal of Lipid Mediators and Cell Signalling·J H Williams
Jun 1, 1994·Current Opinion in Neurobiology·M F Bear, R C Malenka
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Jan 1, 1997·Progress in Neuro-psychopharmacology & Biological Psychiatry·C Hölscher
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Jun 1, 1997·Current Opinion in Neurobiology·J E Brenman, D S Bredt
Oct 16, 2008·Nature Reviews. Neuroscience·Geoffrey A Kerchner, Roger A Nicoll
Oct 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Irina NikonenkoDominique Muller
Jul 1, 1997·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·J H WangP T Kelly
Dec 4, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Zahid Padamsey, Nigel Emptage
Nov 19, 2005·Proceedings of the National Academy of Sciences of the United States of America·Ana LedoJoão Laranjinha
Nov 1, 1995·Neuropharmacology·V Y Bolshakov, S A Siegelbaum
Mar 18, 1994·Brain Research. Developmental Brain Research·J S Fitzpatrick, M Baudry
Jan 11, 2012·Neuroscience and Biobehavioral Reviews·Charles F Zorumski, Yukitoshi Izumi
Oct 24, 2007·Brain Research Reviews·Arthur Giraldi-GuimarãesRosalia Mendez-Otero
Apr 6, 2004·Brain Research. Brain Research Protocols·Tagrid YousefMaxim Volgushev
Oct 27, 2009·Progress in Neurobiology·Steven R Vincent

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