Induction of 16alpha-hydroxylase in cultured human lymphocytes.

Biochemical Genetics
I E MuijssonD L Busbee

Abstract

Lymphocytes grown for 72 hr in the presence of mitogenic agents exhibited a nine-fold increase in 16alpha-hydroxylase activity over a 24-hr period following the addition of 17beta-estradiol as an inducing agent. The major metabolite of 17beta-estradiol produced by induced lymphocytes showed a chromatographic mobility indistinguishable from that of estriol. Enzymatic activity increased linearly with cell numbers, was inhibited by CO, and exhibited no induced increase in the presence of cycloheximide. A population survey indicated about 68% of a randomly selected Caucasian group to be essentially uninducible for 16alpha-hydroxylase.

Citations

Aug 1, 1976·Biochemical Genetics·M L CoomesD L Busbee
Dec 1, 1978·Journal of Steroid Biochemistry·K N Wynne, N Kraft
Jan 1, 1982·Journal of Steroid Biochemistry·L MilewichM K Sawyer
Jan 1, 1984·Journal of Steroid Biochemistry·P ClairA Revol
Mar 1, 1990·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·G ScambiaS Mancuso
Jul 18, 2018·Nature Chemistry·Eugene E KwanEric N Jacobsen
Jul 1, 1980·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F O RanellettiS Iacobelli

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