Induction of a 72-kDa heat shock protein and protection against lipopolysaccharide-induced liver injury in cirrhotic rats

Journal of Gastroenterology and Hepatology
Ken-ichiro MikamiSumio Watanabe

Abstract

A 70-kDa heat shock protein (stress-inducible HSP70, HSP72) has been reported to be a cytoprotectant in a variety of organs. It has been reported that HSP72 protected non-cirrhotic rats against endotoxemia. However, its cytoprotective effect against endotoxemia in cirrhotic rats has not yet been studied. In this study, we investigated the cytoprotective effect of HSP72 on lipopolysaccharide (LPS)-induced liver injury in carbon tetrachloride (CCl(4))-induced cirrhotic rats. Liver cirrhosis was produced by an 8-week intraperitoneal injection of CCl(4) in male Sprague-Dawley rats. Expression of HSP72 was investigated using western blot analysis. Cirrhotic rats were given an intraperitoneal injection of LPS (10 mg/kg) with or without hyperthermia (42.5 degrees C, 15 min) preconditioning. Liver injury was assessed biochemically (aspartate transaminase, alanine transaminase, bilirubin, lactate dehydrogenase, creatinine) and histologically. The plasma tumor necrosis factor (TNF)-alpha level was determined. Hyperthermia preconditioning induced a 4-fold increase in HSP72 in the cirrhotic rat liver. Pre-induction of HSP72 prevented LPS-induced liver injury, as evaluated using serum biochemical parameters and histology with reduced TNF-al...Continue Reading

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Citations

Sep 10, 2011·The British Journal of Nutrition·Motoko OaradaTohru Gonoi
Feb 14, 2007·Journal of Gastroenterology and Hepatology·Guang-Su XiongShu-Dong Xiao
Apr 18, 2006·Biochemistry. Biokhimii︠a︡·E G NovoselovaE E Fesenko
Oct 13, 2007·Doklady Biological Sciences : Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections·G A KustanovaA N Murashev
Oct 17, 2008·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Ching-Hsia HungJuei-Tang Cheng
Nov 14, 2013·Journal of Gastroenterology and Hepatology·Libo LiYabing Xin
Aug 2, 2012·Acta Cirúrgica Brasileira·Thamirys Guimarães MarquesLuiz Augusto Carneiro D'Albuquerque
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Jan 13, 2006·The Journal of Biological Chemistry·Kathleen RuchalskiSteven C Borkan
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Jun 20, 2007·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·S KokuraT Yoshikawa

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