PMID: 15383564Sep 24, 2004Paper

Induction of a CD4+ T regulatory type 1 response by cyclooxygenase-2-overexpressing glioma

The Journal of Immunology : Official Journal of the American Association of Immunologists
Yasuharu AkasakiJohn S Yu

Abstract

PGE(2), synthesized by cyclooxygenase-2 (COX-2)-overexpressing tumor, is known to contribute to cellular immune suppression in cancer patients, but the mechanism remains unclear. We report the mechanism of a CD4(+) T regulatory type 1 (Tr1) induction by CD11c(+) mature dendritic cells (DCs) that phagocytose allogeneic and autologous COX-2-overexpressing glioma. A human glioma cell line, U-87MG, and primary cultured glioblastoma cells (MG-377) overexpressed COX-2. We did not detect IL-10Ralpha expression in these gliomas, and rIL-10 did not suppress their COX-2 expression. Exposure to COX-2-overexpressing glioma induced mature DCs to overexpress IL-10 and decreased IL-12p70 production. These DCs induced a Tr1 response, which is characterized by robust secretion of IL-10 and TGF-beta with negligible IL-4 secretion by CD4(+) T cells, and an inhibitory effect on admixed lymphocytes. Peripheral CD4(+) T cell populations isolated from an MG-377 patient also predominantly demonstrated a Tr1 response against MG-377 cells. Selective COX-2 inhibition in COX-2-overexpressing gliomas at the time of phagocytic uptake by DCs abrogated this regulatory response and instead elicited Th1 activity. COX-2 stable transfectants in LN-18 (LN-18-COX2)...Continue Reading

References

Aug 1, 1992·Journal of Neurosurgery·J SchneiderD R Hinton
Jul 1, 1996·The Journal of Experimental Medicine·H GrouxM G Roncarolo
Jul 4, 1997·The Journal of Biological Chemistry·C C Leslie
Apr 1, 1998·Nature·J Banchereau, R M Steinman
Feb 9, 2000·The Journal of Experimental Medicine·R M SteinmanK Inaba
Mar 1, 2000·Journal of Neuroimmunology·A R DixL A Morford
Sep 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·P R WalkerP Y Dietrich
Mar 13, 2001·Annual Review of Immunology·K W MooreA O'Garra
Aug 15, 2001·Seminars in Immunology·M GunzerS Grabbe
Nov 28, 2001·Immunological Reviews·M G RoncaroloM K Levings
Feb 2, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ganwei LuNikola L Vujanovic
Feb 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hedi HariziNorbert Gualde
Aug 31, 2002·Cancer Immunology, Immunotherapy : CII·Tetsuro KikuchiTsuneya Ohno
Oct 16, 2002·Glia·Manuel B GraeberGeorg W Kreutzberg
Mar 5, 2003·Annual Review of Immunology·Ralph M SteinmanMichel C Nussenzweig
Jul 23, 2003·The Journal of Experimental Medicine·Sayuri YamazakiRalph M Steinman

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Citations

Jun 23, 2005·Stem Cells and Development·Frank P BarryBernard P Mahon
Jul 20, 2005·Expert Review of Neurotherapeutics·Yasuharu AkasakiJohn S Yu
Oct 14, 2005·Expert Review of Anticancer Therapy·S Farzana Hussain, Amy B Heimberger
Sep 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Qing DingKuang-Yen Chou
Sep 19, 2009·Expert Review of Anticancer Therapy·Ana Paula de Souza, Cristina Bonorino
Jan 4, 2012·Cancer Immunology, Immunotherapy : CII·Sofia EberstålPeter Siesjö
May 11, 2012·Neuro-oncology·Wei Li, Manuel B Graeber
Apr 20, 2006·Journal of Neurosurgery·Winan J Van HoudtZeng B Zhu
Nov 15, 2006·Journal of Biomedical Science·Chih-Ping MaoT-C Wu
Apr 9, 2008·Journal of Pediatric Hematology/oncology·Iordanis PelagiadisMaria Kalmanti
Jun 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Milada MahicEinar M Aandahl
Oct 1, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C CourivaudD Ducloux
Oct 20, 2010·Expert Opinion on Biological Therapy·Eyad ElkordDavid E Gilham
Dec 26, 2006·Expert Review of Anticancer Therapy·Henry B Koon, Michael B Atkins
Oct 26, 2012·Journal of Neuro-oncology·Alfred P SeeMichael Lim
Oct 22, 2013·Neurologia Medico-chirurgica·Yohei MineharuSusumu Miyamoto
May 18, 2016·Inflammation·Justyna KiszałkiewiczEwa Brzeziańska-Lasota
May 4, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Emily K BongiornoD Craig Hooper
Dec 7, 2018·PloS One·Corinna SeligerMonika Klinkhammer-Schalke
Jan 30, 2020·International Journal of Cancer. Journal International Du Cancer·Alaa Madi, Guoliang Cui
Feb 13, 2009·Allergy·L Saurer, C Mueller
Jun 23, 2009·Stem Cell Reviews and Reports·Xiaomin ZhangShaozhen Zhao
Aug 15, 2006·Immunological Reviews·Maria Grazia RoncaroloMegan K Levings
Sep 12, 2009·Brain Pathology·Stefaan Van GoolSteven De Vleeschouwer
Jun 16, 2009·Cell Transplantation·Der-Yang ChoShih-Ping Liu
Jun 18, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Murugesan V S RajaramLarry S Schlesinger
Feb 5, 2016·Arkhiv patologii·K E Borisov, D D Sakaeva
Jan 8, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kirsten M HooperDoina Ganea
Jul 15, 2015·BioMed Research International·Liu YangJing Liu

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