PMID: 9444977Aug 1, 1997Paper

Induction of a heterogeneous TCR repertoire in (PL/JXSJL/J)F1 mice by myelin basic protein peptide Ac1-11 and its analog Ac1-11[4A

Molecular Immunology
C I PearsonH O McDevitt

Abstract

Experimental autoimmune encephalomyelitis (EAE) serves as a rodent model of the autoimmune disease multiple sclerosis. In mice, EAE is induced by immunizing with spinal cord homogenate, components of the myelin sheath, such as myelin basic protein (MBP) or proteolipid protein (PLP), or peptides derived from these components. EAE can be induced in H-2u or (H-2u x H-2s)F1 mice with the N-terminal peptide of MBP, Ac1-11. Coimmunization with Ac1-11 and Ac1-11[4A], an analog in which lysine at position four is substituted with alanine, prevents EAE. The mechanism of inhibition has not been elucidated, but probably does not work through MHC blockade, T cell anergy or clonal elimination of encephalitogenic T cells. We have isolated T cell clones and hybridomas from (PL/J x SJL/J)F1 mice immunized with either Ac1-11 alone or Ac1-11 and Ac1-11[4A] and analysed these cells for differences in their T cell receptor repertoire and in vitro response. Although T cells elicited by coinjection of Ac1-11 and Ac1-11[4A] expressed TCR that used V alpha and Vbeta gene elements similar to those elicited by Ac1-11 alone, they differed in the sequences of the junctional region of the alpha chain. Most of these T cells also responded less well to Ac1-1...Continue Reading

References

Feb 1, 1992·European Journal of Immunology·D SunC Coleclough
Nov 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·N K NandaE Sercarz
Nov 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·D E SmilekH O McDevitt
Jul 1, 1991·The Journal of Experimental Medicine·G RubertiA M Livingstone
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·K SakaiL Steinman
May 1, 1989·Immunology Today·E Heber-Katz, H Acha-Orbea
Jan 1, 1989·Immunology Today·J M ClaverieL Bougueleret
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·P A SingerA N Theofilopoulos
Aug 4, 1988·Nature·M M Davis, P J Bjorkman
Feb 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M A BehlkeD Y Loh
Jan 1, 1983·The Journal of Experimental Medicine·K HayakawaL A Herzenberg
Dec 1, 1993·Immunology Today·Y H Chien, M M Davis
Jun 13, 1996·Nature·S M AlamN R Gascoigne
Jan 1, 1996·Annual Review of Immunology·J Sloan-Lancaster, P M Allen

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Citations

Dec 17, 2002·Arthritis and Rheumatism·Linda K MyersAndrew H Kang
Oct 4, 2005·Journal of Immunological Methods·Jennifer MaynardK Christopher Garcia
Oct 1, 2004·Arthritis and Rheumatism·L K MyersA H Kang

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