Induction of a protective immune response against swine Chlamydophila abortus infection in mice following co-vaccination of omp-1 DNA with recombinant MOMP

Zoonoses and Public Health
F ZhangC He

Abstract

Chlamydophila abortus is the causative agent of abortion in pigs and pregnant women. Seroconversion rates were arranged from 11% to 80% in piglets and sows in China. These very high rates illustrate the scale of the problem in China and highlight the urgent need for the development of a C. abortus vaccine. An efficacious anti-chlamydial vaccine should induce not only strong mucosal and systemic T-helper type 1 (Th1) immune response but also give a humoral response that enhances Th1 activation following infection. In order to evaluate an active immune response of a combination of the major outer membrane protein (MOMP) DNA- and protein-based vaccines, 54 BALB/c mice were randomly assigned to six groups and inoculated intramuscularly with: (i) 100 microg pcDNA::MOMP, (ii) 10 microg r-MOMP, (iii) primed with 100 microg pcDNA::MOMP and boosted with 10 microg r-MOMP, (iv) primed-boosted with a combination of pcDNA::MOMP and r-MOMP simultaneously, (v) live-attenuated 1B vaccine, (vi) 100 microg pcDNA3.1 vector. All animals were vaccinated two times at 14 days intervals. Results showed that mice given DNA and r-MOMP induced higher antibody levels, higher T cells proliferation and an elevated level of chlamydial clearance in spleen, wh...Continue Reading

References

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Citations

Feb 15, 2011·Veterinary Research·Katelijn Schautteet, Daisy Vanrompay
Feb 6, 2016·Veterinary Immunology and Immunopathology·Stefanie LagaeDaisy Vanrompay
Apr 7, 2009·Veterinary Microbiology·Annie Rodolakis, Khalil Yousef Mohamad
May 15, 2013·International Immunopharmacology·Changbo OuCheng He
Mar 20, 2012·The International Journal of Biochemistry & Cell Biology·Rajesh Kumar DuttaSekhar Majumdar
Feb 12, 2013·Cytokine & Growth Factor Reviews·Delia GolettiGian Maria Fimia

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