PMID: 9630844Jun 19, 1998Paper

Induction of a SOS repair system in lysogenic bacteria by zearalenone and its prevention by vitamin E

Chemico-biological Interactions
L Ghédira-ChékirHassen Bacha

Abstract

Zearalenone (Zen) is an oestrogenic mycotoxin produced by several Fusarium species in cereals. It induces modifications of haematological parameters in rats with cytotoxicity and inhibition of macromolecular synthesis (nucleic acids and protein). Zen and its metabolites have oestrogenic and anabolic activities and interact with human oestrogen receptors. Zen and its metabolites showed a positive DNA damaging effect in recombination tests with Bacillus subtilis. It induces sister chromatid exchange and chromosomal aberration in CHO cells. Zen was found to be capable of inducing DNA-adduct formation in mouse liver. The genotoxicity of Zen was questionable until the last decade when increasing data tended to show this toxin to be genotoxic in vivo. However the mechanism of its genotoxicity and mutagenicity has not been completely clarified. The present investigations were designed to show whether Zen induces an SOS-DNA repair response in lysogenic bacteria which have an integrated lambda-bacteriophage in their genome. Zen was found to be genotoxic in the bacterial systems from a concentration of 1.50 mM and it was also bactericidal (IC50 = 1.45 mM). In addition vitamin E (6.0-12.0 mM) added 1 h prior to the toxin proved to prevent...Continue Reading

References

Jul 1, 1979·Journal of Toxicology and Environmental Health·D L GreenmanJ L Wittliff
Jan 1, 1978·Journal of Toxicology and Environmental Health·P A Boyd, J L Wittliff
Sep 1, 1987·Regulatory Toxicology and Pharmacology : RTP·T Kuiper-GoodmanH Watanabe
May 14, 1969·Journal of Molecular Biology·H W Boyer, D Roulland-Dussoix
Jun 1, 1994·The Journal of Steroid Biochemistry and Molecular Biology·R J Miksicek
May 1, 1996·Toxicon : Official Journal of the International Society on Toxinology·K MaaroufiH Bacha

❮ Previous
Next ❯

Citations

Apr 11, 2001·Mutation Research·K J Claycombe, S N Meydani
Jun 8, 2002·Toxicology Letters·Edmond E Creppy
Dec 8, 2011·International Journal of Clinical Practice·A PazaitiI S Fentiman
Nov 23, 2006·Applied and Environmental Microbiology·Jan Utermark, Petr Karlovsky
Jan 8, 2013·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Amel Chatti GazzahHassen Bacha
Jul 30, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Imen Ayed-BoussemaWafa Hassen
Jan 21, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Lazhar ZorguiWafa Hassen
Oct 19, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Abdellah ZinedineJordi Mañes
Jul 12, 2007·Journal of Biochemical and Molecular Toxicology·Imen Ayed-BoussemaSalwa Abid
Aug 27, 2019·Critical Reviews in Food Science and Nutrition·Ankita RaiAnurag Tripathi
Feb 24, 2001·Journal of Food Protection·F GalvanoG Galvano
May 5, 2018·Toxins·Wanglong ZhengZongping Liu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacteriophage: Phage Therapy

Phage therapy uses bacterial viruses (bacteriophages) to treat bacterial infections and is widely being recognized as an alternative to antibiotics. Here is the latest research.