PMID: 9544781Apr 17, 1998Paper

Induction of abnormal respiratory sounds by capsaicin in rats previously infected with Bordetella pertussis

FEMS Immunology and Medical Microbiology
R PartonA C Wardlaw

Abstract

Sprague Dawley rats, previously infected with Phase-I Bordetella pertussis, developed more severe abnormal respiratory sounds than normal animals, but not coughing, when exposed to aerosolized capsaicin, one of several cough-inducing agents tested. Stethoscope examination suggested that greater production of pulmonary mucus might be occurring after capsaicin challenge of the infected animals, compared to the uninfected controls. Rats of three other strains gave characteristically different responses from the Sprague Dawleys. The administration of capsaicin to B. pertussis-infected rats may provide useful insights into the pathophysiology of excess mucus secretion in human pertussis.

References

Nov 1, 1975·Medicine·L C Olson
Apr 1, 1989·Infection and Immunity·D E WoodsC Ewanowich
Sep 1, 1984·Pediatric Infectious Disease·M Pittman

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Citations

Sep 22, 1998·Fungal Genetics and Biology : FG & B·G Hyde
Jan 14, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Einat KodeshGregory R Adams

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