Induction of activating transcription factor 3 limits survival following infarct-induced heart failure in mice

American Journal of Physiology. Heart and Circulatory Physiology
Alan C BrooksSteven P Jones

Abstract

Numerous fibrotic and inflammatory changes occur in the failing heart. Recent evidence indicates that certain transcription factors, such as activating transcription factor 3 (ATF3), are activated during heart failure. Because ATF3 may be upregulated in the failing heart and affect inflammation, we focused on the potential role of ATF3 on postinfarct heart failure. We subjected anesthetized, wild-type mice to nonreperfused myocardial infarction and observed a significant induction in ATF3 expression and nuclear translocation. To test whether the induction of ATF3 affected the severity of heart failure, we subjected wild-type and ATF3-null mice to nonreperfused infarct-induced heart failure. There were no differences in cardiac function between the two genotypes, except at the 2-wk time point; however, ATF3-null mice survived the heart failure protocol at a significantly higher rate than the wild-type mice. Similar to the slight favorable improvements in chamber dimensions at 2 wk, we also observed greater cardiomyocyte hypertrophy and more fibrosis in the noninfarcted regions of the ATF3-null hearts compared with the wild-type. Nevertheless, there were no significant group differences at 4 wk. Furthermore, we found no significa...Continue Reading

References

Nov 14, 1998·The American Journal of Physiology·A J PalazzoD J Lefer
Dec 9, 1998·The American Journal of Physiology·A J PalazzoD J Lefer
Aug 13, 1999·The American Journal of Physiology·S P JonesD J Lefer
Nov 13, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·W G GirodD J Lefer
Oct 31, 2000·Circulation Research·M R HoffmeyerD J Lefer
Nov 22, 2000·American Journal of Physiology. Heart and Circulatory Physiology·M R HoffmeyerD J Lefer
Dec 7, 2000·Coronary Artery Disease·S P JonesD J Lefer
Jun 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D J LeferA M Lefer
Jun 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·S P JonesD J Lefer
Aug 9, 2001·Proceedings of the National Academy of Sciences of the United States of America·G CondorelliC M Croce
Nov 14, 2001·Infection and Immunity·W L ChangH C van der Heyde
Dec 18, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·S P JonesD J Lefer
May 11, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Brent R SharpDavid J Lefer
Oct 2, 2002·Journal of the American College of Cardiology·Steven P JonesDavid J Lefer
Dec 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Steven P JonesDavid J Lefer
Feb 11, 2003·The Journal of Biological Chemistry·Jiang YangKenneth Walsh
Apr 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Steven P JonesDavid J Lefer
Sep 13, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Steven P JonesDavid J Lefer
Jun 17, 2004·Molecular and Cellular Biology·Matthew G HartmanTsonwin Hai
Aug 21, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Steven P JonesDavid J Lefer
Jul 18, 2006·American Journal of Physiology. Heart and Circulatory Physiology·James J M GreerDavid J Lefer
Feb 21, 2008·Circulation·Steven P JonesEduardo Marbán
Sep 30, 2010·Proceedings of the National Academy of Sciences of the United States of America·Lewis J WatsonSteven P Jones
Aug 30, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Jianxun WangPaul N Epstein
Apr 26, 2014·Circulation. Heart Failure·Brian E SansburyBradford G Hill
Aug 26, 2014·Journal of Molecular and Cellular Cardiology·Alan C BrooksAruni Bhatnagar

❮ Previous
Next ❯

Citations

Jan 19, 2016·International Journal of Cardiology·Heng ZhouQi-Zhu Tang
May 31, 2016·JCI Insight·Michael A BurkeChristine E Seidman
Jan 14, 2017·Cardiovascular Research·Alessandra GhigoSebastiano Sciarretta
Apr 21, 2016·Circulation. Cardiovascular Genetics·Katey J Rayner, Peter P Liu
Sep 7, 2019·Neuromolecular Medicine·Thierry CoppolaNicolas Blondeau
Aug 11, 2018·Basic Research in Cardiology·Heng ZhouQi-Zhu Tang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.