PMID: 7334009Dec 1, 1981Paper

Induction of acyl-CoA dehydrogenases and electron transfer flavoprotein and their roles in fatty acid oxidation in rat liver mitochondria

Journal of Biochemistry
S FurutaT Hashimoto

Abstract

The capacity of mitochondrial beta-oxidation and activities of three acyl-CoA dehydrogenases and electron transfer flavoprotein in rat liver were increased after administration of peroxisome proliferators such as di(2-ethylhexyl)phthalate or p-chlorophenoxyisobutyrate. Oxygen consumption by mitochondrial beta-oxidation with palmitate, palmitoyl-CoA or palmitoylcarnitine was in the range of 0.27-0.41 mumol O2/min per g liver and the dehydrogenase activity with palmitoyl-CoA was 0.56 mumol/min per g liver. These activities were increased, after administration of peroxisome proliferators, to 0.80-1.23 mumol O2/min per g liver and 1.06-1.08 mumol/min per g liver, respectively. The time required to reach half-maximal induction of the three acyl-CoA dehydrogenases and electron transfer flavoprotein after administration of di(2-ethylhexyl)phthalate was about 5 days. On the withdrawal of the agent, the activities of these flavoproteins decreased to the control levels with half-lives of about a day.

Citations

Jan 1, 1982·Annals of the New York Academy of Sciences·T Hashimoto
Sep 1, 1982·Lipids·T SakuraiT Hashimoto
Jan 15, 1998·Critical Care Medicine·W WangI H Chaudry
Jul 1, 1993·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·H PermadiJ W DePierre
May 1, 1987·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·B Lundgren, J W DePierre
Oct 15, 1983·Archives of Biochemistry and Biophysics·H IshiiT Suga

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