Induction of allograft nonresponsiveness after intrathymic inoculation with donor class I allopeptides. I. Correlation of graft survival with antidonor IgG antibody subclasses

Transplantation
A MhoyanH Shirwan

Abstract

We have recently demonstrated that cardiac allograft rejection in the PVG.R8-to-PVG.1U rat strain combination involves the recognition of a isolated class I (RT1.Aa) molecules as peptides in the context of the recipient MHC molecules. Three synthetic peptides (P1, P2, and P3) corresponding to the alpha-helices of the RT1.Aa molecule served as T-cell epitopes for graft rejection. In this study, we demonstrate that two of these peptides (P2 and P3) are sufficient to induce immune nonresponsiveness (median survival time >237 days) to cardiac allografts when presented to the recipient immune system in the thymus 7 days before transplantation. This effect was time dependent, as intrathymic inoculation 60 days before transplantation did not prolong graft survival (median survival time=12 days). Previous studies have demonstrated a critical role for alloantibody responses in mediating graft rejection in this rat strain combination. We, therefore, studied the role alloantibody responses may play in the observed immune nonresponsiveness. The titers of alloantibody in serum samples harvested from graft recipients at different times after transplantation were measured. We used recipient primary aortic endothelial cells genetically manipul...Continue Reading

References

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Citations

Mar 27, 2001·Transplantation Proceedings·M Spadafora-FerreiraV Coelho
Dec 26, 2001·Transplantation Proceedings·G J PettigrewJ A Bradley
Sep 2, 1998·Transplantation Proceedings·C C Magee, M H Sayegh
Mar 20, 1999·Transplantation Proceedings·A MhoyanH Shirwan
Mar 16, 2004·Pediatric Diabetes·Rita BottinoMassimo Trucco
Mar 2, 2011·Current Cardiovascular Imaging Reports·Yijen L WuChien Ho
Dec 18, 2009·Expert Review of Molecular Diagnostics·Josep-Maria Pujal
May 20, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Haval ShirwanSherif Ibrahim
Nov 18, 2003·Immunological Reviews·Maria P Hernandez-FuentesRobert I Lechler
Apr 9, 2005·Transplant Immunology·A PawlikB Gawronska-Szklarz
Dec 1, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·M Spadafora-FerreiraV Coelho
May 26, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·K L WomerM H Sayegh
Aug 4, 2004·Cell Biochemistry and Biophysics·Soji F OluwoleHector A DePaz
Apr 20, 2016·Frontiers in Immunology·Hua PanMauricette Michallet
May 25, 2005·Pediatric Transplantation·Dax A Guenther, Joren C Madsen
Jun 27, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·T H StadlbauerM H Sayegh
Dec 6, 2006·The Orthopedic Clinics of North America·Allen T Bishop, Michael Pelzer

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