Induction of alloreactive CD4 T cell tolerance in molecular chimeras: a possible role for regulatory T cells

The Journal of Immunology : Official Journal of the American Association of Immunologists
Daron FormanJohn Iacomini

Abstract

Induction of molecular chimerism following reconstitution of mice with autologous bone marrow cells expressing a retrovirally encoded allogeneic MHC class I Ag results in donor-specific tolerance. To investigate the mechanism by which CD4 T cells that recognize allogeneic MHC class I through the indirect pathway of Ag presentation are rendered tolerant in molecular chimeras, transgenic mice expressing a TCR on CD4 T cells specific for peptides derived from K(b) were used. CD4 T cells expressing the transgenic TCR were detected in mice reconstituted with bone marrow cells transduced with retroviruses carrying the gene encoding H-2K(b), albeit detection was at lower levels than in mice receiving mock-transduced bone marrow. Despite the presence of CD4 T cells expressing an alloreactive TCR, mice receiving H-2K(b)-transduced bone marrow permanently accepted K(b) disparate skin grafts. CD4+CD25+ T cells from mice reconstituted with H-2K(b)-transduced bone marrow prevented rejection of K(b) disparate skin grafts when adoptively transferred into immunodeficient mice along with effector T cells, suggesting that induction of molecular chimerism leads to the generation of donor specific regulatory T cells, which may be involved in preve...Continue Reading

References

Jun 1, 1997·Immunological Reviews·R Parkman, K I Weinberg
Jul 27, 1997·Transplantation·T SawadaJ Iacomini
Feb 5, 1999·European Journal of Immunology·M WiseH Waldmann
Mar 23, 2001·Nature Immunology·J BagleyJ Iacomini
May 5, 2001·Immunity·M Sykes
Nov 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·P S RussellR B Colvin
Aug 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eun-Suk Kang, John Iacomini
Sep 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chaorui TianJohn Iacomini
Nov 5, 2002·Nature Immunology·Chun-Yen LinHerman Waldmann
Feb 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Matthew A WilliamsChristian P Larsen
Mar 27, 2003·Nature Reviews. Immunology·Kathryn J Wood, Shimon Sakaguchi
Sep 15, 2004·Trends in Immunology·Josef KurtzMegan Sykes
Jun 9, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·Daron FormanJohn Iacomini

❮ Previous
Next ❯

Citations

Nov 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chaorui TianJohn Iacomini
Jun 29, 2007·International Archives of Allergy and Immunology·Ines PreeThomas Wekerle
Aug 19, 2007·Transplantation·Jessamyn BagleyJohn Iacomini
Jul 19, 2012·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·U BaranyiT Wekerle
Jul 10, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C TianJ Iacomini
Jul 11, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C TianJ Iacomini

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
Jessamyn BagleyJohn Iacomini
The Journal of Immunology : Official Journal of the American Association of Immunologists
Eun-Suk Kang, John Iacomini
Molecular Therapy : the Journal of the American Society of Gene Therapy
Daron FormanJohn Iacomini
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Chaorui TianJohn Iacomini
The Journal of Immunology : Official Journal of the American Association of Immunologists
Chaorui TianJohn Iacomini
© 2021 Meta ULC. All rights reserved