PMID: 2434431Nov 1, 1986

Induction of an atypical interferon by bacteroides fragilis and Escherichia coli in experimental infections and in leukocyte cultures

Infection
D K BlanchardH Friedman

Abstract

Previous reports have shown that Bacteroides fragilis may enhance the pathogenicity of coinfecting enterobacteriaceae by interfering with the host's immune response. With the present study, we have investigated the possible role of interferons (IFN) in mediating these effects. Mice injected with B. fragilis developed moderate serum levels of IFN that appeared just prior to alterations of the animals' immunity described earlier. The IFN was neutralized by treatment with anti-IFN-alpha/beta-antibodies or hydrochloric acid; hence it displayed the same "atypical" characteristics as IFN found in patients with immuno-compromising diseases such as AIDS, systemic lupus erythematosus or rheumatoid arthritis. Escherichia coli displayed the same induction patterns as B. fragilis, while gram-positive bacteria induced "regular" IFN alpha/beta and gamma. Spleen cells, peritoneal macrophages, or liver leukocytes taken from B. fragilis or E. coli-injected animals 6 h post infection were refractory to IFN induction by E. coli lipopolysaccharide in vitro; cells from mice infected with gram-positive organisms showed normal or enhanced responsiveness.

References

Jan 1, 1977·Infection and Immunity·N Maehara, M HO
Dec 17, 1977·Lancet·H R InghamA A Codd
Jun 1, 1977·Journal of Clinical Pathology·D TharagonnetJ B Selkon
Jul 5, 1979·The New England Journal of Medicine·J J HooksA L Notkins
Jan 1, 1976·Infection and Immunity·A B OnderdonkS L Gorbach
May 1, 1986·Infection and Immunity·A C RodloffH Friedman
Jul 1, 1973·The Journal of Infectious Diseases·M HOJ A Armstrong
Aug 1, 1965·Proceedings of the Society for Experimental Biology and Medicine·M HOM K Breinig
Feb 1, 1981·Journal of Interferon Research·M Wiranowska-Stewart, W E Stewart
Oct 1, 1984·Zentralblatt Für Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology·A C Rodloff, H Hahn
Oct 1, 1982·The Journal of Infectious Diseases·E DeStefanoJ Vilcek
May 22, 1964·Science·J S YOUNGNER, W R STINEBRING

Citations

Jan 1, 1994·Biotechnology Advances·L A Babiuk, A A Potter
Dec 22, 1999·Clinical and Experimental Immunology·R AttanasioH M McClure

Related Concepts

Metazoa
Bacteroides fragilis
Bacteroides Infections
Alkalescens-Dispar Group
Escherichia Coli Infections
Natural Immunosuppression
Interferons
Leukocytes
Listeria monocytogenes
Streptococcus pneumoniae

Related Feeds

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

© 2021 Meta ULC. All rights reserved