PMID: 8940724Aug 1, 1996Paper

Induction of an experimental Fanconi syndrome in mice: its effect on the glomerular filtration function studied by 99mTc-DTPA

Nuclear Medicine and Biology
C Sawas-DimopoulouL Margaritis

Abstract

An experimental mice model of maleate (MAL)-induced Fanconi syndrome has been used to test 99mTc-DTPA ability to detect hampered glomerular filtration rate (GFR) early in drug-induced Fanconi syndrome. In fact, declining GFR has been reported both in idiopathic and acquired Fanconi syndrome. The above MAL model shows urine biochemistry changes similar to those reported in patients suffering from Fanconi syndrome. Moreover, biodistribution study and whole-body autoradiographies performed after IV injection of 99mTc-DTPA in MAL and control mice show significantly delayed pharmacokinetics of the above radiopharmaceutical in a MAL dose-dependent effect. After administration of a MAL dose of 6 mM/kg BW, the 5-min biodistribution of 99mTc-DTPA, a radiopharmaceutical freely excreted by glomerular filtration, is significantly changed in all organs. In blood of MAL mice, 27.62 +/- 2.86% of the injected dose is still circulating compared to 13.67 +/- 1.22% of the injected dose in control mice, and only 1.37 +/- 0.31% of the injected dose has been excreted in urine of MAL mice compared to 24.66 +/- 4.12% of the injected dose in urine of control mice. The obtained results suggest that 99mTc-DTPA may be efficient both in the early detection...Continue Reading

References

Oct 1, 1976·The American Journal of Physiology·A GougouxN Lavoie
Oct 1, 1976·The American Journal of Physiology·M Silverman, L Huang
Nov 1, 1979·Pflügers Archiv : European journal of physiology·R GüntherP Deetjen
Aug 1, 1976·The American Journal of Physiology·S F Wen
May 1, 1976·The Journal of Clinical Investigation·M BergeronC Schwab
Sep 1, 1992·Canadian Journal of Physiology and Pharmacology·J F PouliotR Béliveau
Aug 1, 1990·The Journal of Pediatrics·C D BurkA T Meadows
Jan 1, 1989·Nephron·J W Foreman, K S Roth
Jan 1, 1985·Uremia Investigation·A P Provoost, M Van Aken
Sep 1, 1974·The Biochemical Journal·A G Booth, A J Kenny
Jan 1, 1972·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·K SchärerJ Metcoff
Jan 1, 1984·European Journal of Nuclear Medicine·W H van LuijkD A Piers
Jan 1, 1983·European Journal of Nuclear Medicine·W H van LuÿkD A Piers
Aug 1, 1993·The Journal of Pediatrics·M B LandeL M Guay-Woodford
Jan 1, 1995·The American Journal of the Medical Sciences·S Eiam-OngN A Kurtzman
Nov 1, 1993·Pediatric Pathology·E Hawkins, E Brewer
Jan 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J Z MelnickJ R Thompson
Nov 1, 1995·Kidney International·S Eiam-ongS Sabatini
Dec 1, 1950·Proceedings of the Society for Experimental Biology and Medicine·R W BERLINERJ G HILTON

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.