Induction of and recovery from tolerance to the discriminative stimulus properties of l-cathinone

Pharmacology, Biochemistry, and Behavior
M D Schechter

Abstract

Rats previously trained to discriminate between 0.6 mg/kg l-cathinone and saline in a two-lever, food-motivated operant task were administered l-cathinone at the same dose, every 8 hours for 10 days. Discrimination testing during this chronic administration phase of experimentation indicated that the animals' ability to discriminate both 0.3 and 0.6 mg/kg l-cathinone decreased when compared to their discriminative ability prior to chronic administration. In contrast, discrimination of the non-drug state, i.e., saline, was not affected. Comparison of dose-response curves prior to and during chronic cathinone administration indicated a 3-4 fold shift to the right for the latter curve. Continued testing after termination of chronic treatment resulted in a return to pre-chronic discriminative performance by the fifteenth day after cessation. These results indicate that tolerance to the discriminative effects of l-cathinone can be produced within 10 days of chronic administration and recovery from this observed tolerance occurs within 15 days of cessation of chronic administration.

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Nov 1, 1987·Pharmacology, Biochemistry, and Behavior·D M WoodM W Emmett-Oglesby
Jan 1, 1990·Pharmacology & Therapeutics·P Kalix
Jun 20, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Anteneh M Feyissa, John P Kelly
May 14, 2008·Substance Use & Misuse·Manuela GrazianiPaolo Nencini
Dec 2, 2005·Addiction Biology·Nezar N Al-Hebshi, Nils Skaug

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