Induction of anti-mistletoe lectin antibodies in relation to different mistletoe-extracts

Anti-cancer Drugs
G M SteinP A Berg

Abstract

Mistletoe extracts are frequently applied in adjuvant cancer treatment. The mistletoe lectins are especially suggested to mediate an antitumorous effect. During treatment with mistletoe lectin-rich extracts, anti-mistletoe lectin antibodies preferentially of the immunoglobulin G type are produced against mistletoe lectin (ML)-1. Interestingly, after application of mistletoe extracts containing natural micelles, anti-mistletoe lectin antibodies of the immunoglobulin G as well as one of the immunoglobulin E type were induced in parallel, suggesting that the nature and preparation of the antigens within the extract modifies immune responses. Anti-mistletoe lectin antibodies were shown to neutralize the cytotoxic effect of mistletoe lectin on peripheral blood mononuclear cells in vitro. Thus, the mode of application of these extracts seems to be of importance with respect to the therapeutic effect.

Citations

Oct 3, 2002·Cancer Letters·Oliver GalmRainhardt Osieka
Dec 16, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G M Stein, P A Berg
Apr 6, 2005·Drug Discovery Today·Bhushan Patwardhan, Manish Gautam
May 22, 2016·Integrative Cancer Therapies·Maurice OrangeUwe Hobohm

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