PMID: 9180360Jan 1, 1997Paper

Induction of antioxidant enzymes by dexamethasone in the adult rat lung

Life Sciences
H J JoséV R Cecilia

Abstract

Catalase, glutathione peroxidase and superoxide dismutase enzymes were determined after administering dexamethasone. Catalase increased its activity over six times (0.388 U/mg DNA) the normal rate, while glutathione peroxidase caused 3 times an increase one hour after dexamethasone injection. Superoxide dismutase increased gradually during the 3 hour treatment. The antioxidant enzyme activities decreased to basal values in the presence of protein synthesis (Cycloheximide) and RNA synthesis (Actinomycin D) inhibitors. The current report demonstrates that the increase of antioxidant enzymes is due to an enzymatic induction mechanism, and not due to an activation process.

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Citations

Oct 21, 2006·Respirology : Official Journal of the Asian Pacific Society of Respirology·Anna M SadowskaWilfried A De Backer
Apr 13, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Philip L BallardMichael A Matthay
Apr 3, 2014·Neurology Research International·Maha GamalNivin Sharawy
Dec 17, 2011·Canadian Journal of Physiology and Pharmacology·Muhammad Y Al-ShorbagyDalaal M Abdallah
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Oct 16, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Nuzzi RaffaeleDario Ghigo
May 11, 2019·Bioscience Reports·Bing WanXiuwei Zhang
Jul 12, 2018·Oxidative Medicine and Cellular Longevity·Ahmed E ZayedAhmed M Kotb
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Apr 18, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Young-Hoon KimMyung-Suk Kim

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