Abstract
Jaspolide B is a novel isomalabaricane-type triterpene isolated from sponge Jaspis sp. We investigated its effects on human hepatoma cells in this study. After 48 h of incubation, jaspolide B inhibited the growth of Bel-7402 and HepG2 cells with IC(50) values of 29.1 and 29.5 μM, respectively. Incubation with 0.5 μM of jaspolide B caused time-dependent induction of apoptosis in up to 66.8% of Bel-7402 cells for 48 h, and the induction of apoptosis was confirmed by the enhancement of mitochondrial masses and cell membrane permeability, and nuclear condensation in Bel-7402 and HepG2 cells. Moreover, jaspolide B arrested cell cycle progression at G(1) phase of human hepatoma cells in a dose- and time-dependent manner. In addition, treatment of the compound caused dose-dependent disassembly of microtubule cytoskeleton in Bel-7402 cells at indicated concentrations, and this effect being similar but weaker than that of colchicine, a well-known microtubule-disassembly agent. We conclude that the anti-cancer effect of jaspolide B relates to the apoptosis induction, cell cycle arrest and microtubule disassembly, and these multiple mechanisms of jaspolide B, especially the induction of apoptosis, open interesting perspectives for further...Continue Reading
References
Jul 4, 1990·Journal of the National Cancer Institute·P SkehanM R Boyd
Aug 1, 1988·Pflügers Archiv : European journal of physiology·J HeschelerW Trautwein
Dec 1, 1988·Journal of Muscle Research and Cell Motility·A Takai
Apr 1, 1983·Journal of Cellular Physiology·S M Ribeiro, H A Armelin
Aug 1, 1995·Biochemistry·R BaiE Hamel
Jun 1, 1995·Current Opinion in Cell Biology·W C Earnshaw
Apr 1, 1996·British Journal of Cancer·M García-RochaJ Avila
May 1, 1997·Journal of Natural Products·T C McKeeM R Boyd
Apr 2, 1998·Experimental Cell Research·S Camilleri-BroëtD Hockenbery
Apr 29, 1998·Annual Review of Physiology·G KroemerM Resche-Rigon
Aug 12, 1998·Journal of Cellular Physiology·H TanakaT Yagura
Aug 28, 1998·Science·D R Green, J C Reed
Aug 14, 1999·Cancer Chemotherapy and Pharmacology·A A GeldofG T Faircloth
Dec 2, 1999·Cell Biology International·A A SablinaB P Kopnin
Mar 30, 2001·Journal of Natural Products·K M MeragelmanM R Boyd
Feb 23, 2002·Journal of Natural Products·Deniz TasdemirChris M Ireland
Apr 19, 2002·Carcinogenesis·Min LiJeanne Leung-Tack
Jul 11, 2002·British Journal of Cancer·A Carnero
Aug 22, 2002·Current Cancer Drug Targets·Angela CasiniLaudiu T Supuran
Nov 9, 2002·Journal of Biotechnology·Wei ZhangMaicun Deng
Dec 8, 2004·Mini Reviews in Medicinal Chemistry·Mohd N Islam, Magdy N Iskander
Jan 27, 2005·Assay and Drug Development Technologies·Richik N GhoshOleg Lapets
Oct 26, 2005·Biochemical Society Transactions·C W Gourlay, K R Ayscough
Oct 29, 2005·Cancer Letters·W K LiuC T Che
Oct 29, 2005·Planta medica·Minjuan XuMin Li
Nov 12, 2005·Pharmacology·Shuichiro HayashiYuichi Majima
Jan 6, 2006·Chemical & Pharmaceutical Bulletin·Shengan TangWenhan Lin
Jun 3, 2006·Cancer Letters·Haizhen WangZhi-Ren Liu
Sep 26, 2006·Medical Hypotheses·Wade A Russu
Jul 22, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alessia MontagnoliFrancesco Colotta
Feb 22, 2012·Marine Pollution Bulletin·Clive Wilkinson, Bernard Salvat
Citations
Sep 26, 2009·Natural Product Reports·Reen-Yen KuoKuo-Hsiung Lee
Dec 4, 2012·Marine Drugs·Ming LiuXiukun Lin
Apr 15, 2010·Marine Drugs·Sherif S EbadaPeter Proksch
Dec 2, 2011·Marine Drugs·Magbubah EssackJohn A C Archer
Jul 17, 2014·Marine Drugs·Sheng-An TangDexin Kong
Oct 6, 2016·PloS One·Mixue XieXiujin Ye
Oct 14, 2017·Marine Drugs·Cinzia CalcabriniCarmela Fimognari
Feb 23, 2011·Phytotherapy Research : PTR·Xiaobing CaiWei Hu
Apr 22, 2016·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Wei-Guo XuSheng-An Tang
Jul 3, 2021·Marine Drugs·Valentin A Stonik, Sophia A Kolesnikova
Feb 13, 2018·Journal of Natural Products·John H MillerPeter T Northcote
Oct 28, 2019·Journal of Natural Products·Sophia A KolesnikovaValentin A Stonik
Dec 19, 2019··Taufik Adhi Prasetya WardanaTri Rini Nuringtyas