Induction of Apoptosis and Inhibition of Epithelial Mesenchymal Transition by α -Mangostin in MG-63 Cell Lines

Evidence-based Complementary and Alternative Medicine : ECAM
Sung-Jin ParkIn-Ryoung Kim

Abstract

Osteosarcoma is the most common bone primary malignant tumor and nearly 30% of patients still die from osteosarcoma due to metastasis or recurrence. Thus, it is necessary to develop effective new chemotherapeutic agents for osteosarcoma treatment. α-Mangostin is a xanthone derivative shown to have antioxidant and anticarcinogen properties. However, the molecular mechanisms underlying the antimetastatic effects of osteosarcoma remain unclear. In metastasis progression, epithelial mesenchymal transition (EMT) is a process that plays important roles in development, cell polarity, and increased invasion and migration. This study focused on the induction of apoptosis and inhibition of EMT process by α-mangostin in human osteosarcoma cell line MG63. α-Mangostin treatments on MG63 cells not only showed the several lines of evidence of apoptotic cell death but also inhibited cell migration, invasion, and EMT-inducing transcription factor. In conclusion, we demonstrate that the α-mangostin induces apoptosis via mitochondrial pathway and suppresses metastasis of osteosarcoma cells by inhibiting EMT.

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Citations

Nov 27, 2018·Cancer Biomarkers : Section a of Disease Markers·Wei YangZhandong Zhang
Nov 30, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Su-Bin YuIn-Ryoung Kim
Nov 23, 2020·Environmental Science and Pollution Research International·Ajay KumarSatwinderjeet Kaur

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Methods Mentioned

BETA
flow cytometry
electrophoresis
FACS
light microscopy

Software Mentioned

Sequence Detection System
image J

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