PMID: 11312158Apr 20, 2001Paper

Induction of apoptosis and necrosis by zinc in human thyroid cancer cell lines

The Journal of Endocrinology
M IitakaS Katayama

Abstract

Zinc at concentrations of 150, microM or higher induced necrosis as well as apoptosis in thyroid cancer cell lines. Necrosis was induced by zinc in a dose-dependent manner, whereas apoptosis did not increase at higher concentrations of zinc. The expression of the antiapoptotic protein phosphorylated Bad was markedly increased, whereas the expression of the proapoptotic proteins Bax and Bad decreased following Zn(2+) exposure. Zn(2+) induced rapid degradation of IkappaB, and an increase in the binding of nuclear transcription factor-kappaB (NF-kappaB). These observations indicate that antiapoptotic pathways were activated in thyroid cancer cells following exposure to Zn(2+). This may be a self-defence mechanism against apoptosis and may underlie the general resistance of thyroid cancer cells to apoptotic stimuli. Zinc may be a potential cytotoxic agent for the treatment of thyroid cancer.

Citations

Jan 18, 2003·The International Journal of Biochemistry & Cell Biology·Fan WangHai-Meng Zhou
Feb 13, 2010·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Emil Rudolf, Miroslav Cervinka
Jun 1, 2007·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Andrew P Smith, Nancy M Lee
Sep 1, 2015·International Journal of Oncology·Alessia GarufiGabriella D'Orazi
Jun 6, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Akio KinazakiYasuo Oyama
Jan 7, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Yoko SakanashiYasuo Oyama
Nov 6, 2007·International Journal of Radiation Oncology, Biology, Physics·Li-Ching LinChing-Hsiung Chang
Jun 30, 2005·International Journal of Cancer. Journal International Du Cancer·Grit KasperKerstin Lehmann
Oct 13, 2014·Environmental Toxicology and Pharmacology·Lingying ZhongPei Zhou
Jun 12, 2013·Free Radical Biology & Medicine·Weidong WuJames M Samet
May 18, 2016·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Heidi HsiehMary Beth Genter
Jul 2, 2014·Human & Experimental Toxicology·H HsiehM B Genter

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