Induction of apoptosis and regression of spontaneous dog melanoma following in vivo application of synthetic cyclin-dependent kinase inhibitor olomoucine

Anti-cancer Drugs
M HajdúchM Strnad

Abstract

This case report describes a dog with spontaneous melanoma of the orofacial region which was treated by a synthetic inhibitor of cyclin-dependent kinases, i.e. olomoucine (OC). The drug was applied i.v. in a single dose of 8 mg/kg/day for 7 days in succession. Repeated bioptic examinations of metastatic cervical lymph nodes showed rapid induction of apoptosis in tumor cells as early as on the third day of treatment. Standard clinical and laboratory examinations did not reveal side effects of the therapy. There were no detectable manifestations of myelosuppression, hepatotoxicity, nephrotoxicity or neurotoxicity. However, transient anemia developed following bleeding from a devitalized tumor mass. For this reason, the dog underwent surgery to minimize tumor load as well as to eliminate the source of bleeding. Two kilograms of primary tumor were extirpated in the course of surgery, including cervical node metastases. Unfortunately, the dog died soon after surgery due to respiratory depression. Histological examinations of the tumor tissue showed marked apoptosis of melanoma cells in both the primary tumor and metastases. The induction of programmed cell death of cancer cells by OC resulted in rapid eradication of at least 68% of ...Continue Reading

Citations

Apr 8, 2006·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Eva AnzenbacherováPavel Anzenbacher
Oct 11, 2005·Bioorganic & Medicinal Chemistry·Karel DolezalMiroslav Strnad
Feb 24, 2007·Cancer Chemotherapy and Pharmacology·Hairong SongZuzana Hassan
Jun 20, 2003·Cell Proliferation·Katrien VermeulenZwi N Berneman
Mar 11, 1999·Current Opinion in Genetics & Development·M D Garrett, A Fattaey
Jun 30, 2011·Journal of Medicinal Chemistry·Aurelie BourderiouxMichal Hocek

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